PMID- 21664595
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20120227
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 152
IP  - 2
DP  - 2011 Aug
TI  - Natural course of adult-onset foveomacular vitelliform dystrophy: a 
      spectral-domain optical coherence tomography analysis.
PG  - 304-13
LID - 10.1016/j.ajo.2011.01.047 [doi]
AB  - PURPOSE: To describe the natural course of adult-onset foveomacular vitelliform 
      dystrophy using spectral-domain optical coherence tomography (SD-OCT). DESIGN: 
      Retrospective study. METHODS: We reviewed the charts of all consecutive patients 
      with adult-onset foveomacular vitelliform dystrophy who underwent SD-OCT at 
      baseline and at least 12 months later (last visit). Main outcome measures were 
      changes of clinical and SD-OCT features over time. RESULTS: Forty-six eyes (31 
      patients, 15 male and 16 female; mean age 74.6 +/- 8.2 years) were included. 
      Follow-up was 16.2 +/- 6 (range, 12-30) months. Visual acuity (VA) reduced from 
      0.32 +/- 0.22 logMAR at baseline to 0.39 +/- 0.28 logMAR at last visit (P=.03). The 
      stage of the disease was vitelliform in 28 eyes (60.8%), pseudohypopyon in 7 eyes 
      (15.2%), vitelliruptive in 11 eyes (23.9%) at baseline; vitelliform in 23 eyes 
      (50%), pseudohypopyon in 5 eyes (10.9%), vitelliruptive in 13 eyes (28.2%), and 
      atrophic in 5 eyes (10.9%) at last visit. Stabilization of the disease stage, 
      inner segment/outer segment (IS/OS) interface status, and lesion reflectivity on 
      SD-OCT determined no VA changes (P>.05), while their worsening determined a 
      reduction of VA (P=.03). In eyes that presented a progression of the disease 
      stage, mean central macular thickness, maximal thickness of the lesion, and 
      maximal width of the lesion showed a significant change (from 404.1 +/- 107.6 mum to 
      246.1 +/- 74.0 mum, P = .004; from 277.0 +/- 80.8 mum to 105.3 +/- 92.3 mum, P=.001; from 
      2324.2 +/- 1250.3 mum to 1751.0 +/- 858.3 mum, P = .04, respectively). CONCLUSIONS: In 
      adult-onset foveomacular vitelliform dystrophy, progression of the lesion stage 
      (partial/complete resorption of the material) is generally accompanied by IS/OS 
      interface disruption/loss and visual impairment.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      University Paris XII, Creteil, France. giuseppe.querques@hotmail.it
FAU - Forte, Raimondo
AU  - Forte R
FAU - Querques, Lea
AU  - Querques L
FAU - Massamba, Nathalie
AU  - Massamba N
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Journal Article
DEP - 20110612
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2012 Feb;153(2):389; author reply 389-90. PMID: 22264960
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Retinal Photoreceptor Cell Inner Segment/*physiology
MH  - Retinal Photoreceptor Cell Outer Segment/*physiology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Vision Disorders/*physiopathology
MH  - Visual Acuity/physiology
MH  - Vitelliform Macular Dystrophy/*physiopathology
EDAT- 2011/06/15 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/06/14 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2011/01/04 00:00 [revised]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - S0002-9394(11)00117-6 [pii]
AID - 10.1016/j.ajo.2011.01.047 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2011 Aug;152(2):304-13. doi: 10.1016/j.ajo.2011.01.047. Epub 
      2011 Jun 12.