PMID- 21664939
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20211203
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 9
DP  - 2011 Sep
TI  - Characterization of the major histocompatibility complex class I chain-related 
      gene B (MICB) polymorphism in a northern Chinese Han population: the 
      identification of a new MICB allele, MICB*023.
PG  - 727-32
LID - 10.1016/j.humimm.2011.05.013 [doi]
AB  - Major histocompatibility complex class I chain-related gene B (MICB) has only 
      been characterized for allelic variation in very few human populations. The MICB 
      polymorphism remains largely unknown in Chinese populations. In this study, 104 
      healthy unrelated Han subjects recruited from central Inner Mongolia Autonomous 
      Region, northern China, were investigated by sequence-based typing for MICB 
      allelic variation, the association of MICB alleles with AluyMICB 
      insertion/deletion dimorphism located in MICB intron 1, linkage disequilibrium of 
      MICB with human leukocyte antigen (HLA)-B and MICA, and HLA-A-C-B-MICA-MICB 
      haplotypic diversity. Ten kinds of MICB alleles were observed, among which 
      MICB*005:02/010, MICB*002:01, and MICB*004:01 were the most frequent alleles with 
      frequencies of 51.44, 16.35, and 11.54%, respectively. Significant linkage 
      disequilibrium (LD) was observed for 9 of the 21 HLA-B-MICB haplotypes and 6 of 
      the 17 MICA-MICB haplotypes with a frequency >1.5%. In particular, HLA-B*13:01 
      and HLA-B*13:02, both of which were frequently represented in this population, 
      exhibited a distinct LD pattern with the MICB allele. A new MICB allele, 
      MICB*023, was identified, which differed from MICB*005:02/010 by a single 
      mutation of G to A at position 86 in exon 2, resulting in an amino acid change 
      from arginine to histidine at codon 6. 
      HLA-A*30-C*06-B*13:02-MICA*008:01-MICB*005:02/010 was the most common haplotype, 
      with a frequency of 8.64% in this population. 
      HLA-A*02-C*08-B*48-MICA*Del-MICB*009N demonstrated a frequency of 2.4% in this 
      population. Our results provide for the first time data regarding the MICB 
      genetic polymorphism in northern Chinese Han populations and will form the basis 
      for future studies of the potential role of MICB in allogeneic organ 
      transplantation and disease association in related ethnic groups.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Liu, XueXiang
AU  - Liu X
AD  - Department of Immunology, College of Basic Medical Sciences, Central South 
      University, Changsha, Hunan, China.
FAU - Tian, Wei
AU  - Tian W
FAU - Li, LiXin
AU  - Li L
FAU - Cai, JinHong
AU  - Cai J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110524
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MICB antigen)
SB  - IM
MH  - *Alleles
MH  - China
MH  - *Ethnicity
MH  - Female
MH  - Gene Frequency
MH  - Genotyping Techniques
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Mutation/*genetics
MH  - Polymorphism, Genetic
MH  - Transplantation Immunology/genetics
EDAT- 2011/06/15 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/01/25 00:00 [received]
PHST- 2011/04/27 00:00 [revised]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0198-8859(11)00120-0 [pii]
AID - 10.1016/j.humimm.2011.05.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Sep;72(9):727-32. doi: 10.1016/j.humimm.2011.05.013. Epub 2011 
      May 24.