PMID- 21665206 OWN - NLM STAT- MEDLINE DCOM- 20120405 LR - 20171116 IS - 1879-1484 (Electronic) IS - 0021-9150 (Linking) VI - 218 IP - 1 DP - 2011 Sep TI - Skin autofluorescence is inversely related to HDL anti-oxidative capacity in type 2 diabetes mellitus. PG - 102-6 LID - 10.1016/j.atherosclerosis.2011.05.011 [doi] AB - OBJECTIVE: High density lipoprotein (HDL) particles protect apolipoprotein B-containing lipoproteins from oxidative modification. An impaired anti-oxidative functionality of HDL in type 2 diabetes mellitus (T2DM) may contribute to enhanced formation of oxidative stress products, such as Advanced Glycation Endproducts (AGEs). We tested whether in T2DM the HDL anti-oxidative capacity is related to the accumulation of AGEs in the skin. METHODS: Skin autofluorescence (AF), a non-invasive read-out for AGEs, and HDL anti-oxidative capacity, i.e. the ability of HDL to protect against LDL oxidation in vitro, were assessed in 67 non-smoking T2DM patients without complications (median age: 60 (53-65), 60% males, 6.5 (5.2-8.5) years of diabetes duration). RESULTS: In univariate analysis, skin AF correlated inversely with HDL anti-oxidative capacity (r=-0.305, P<0.02), but not with HDL cholesterol or apolipoprotein A-I. HDL anti-oxidative capacity correlated inversely with glucose, HbA(1c), triglycerides, and insulin resistance (homeostasis model assessment) (P<0.05 to P