PMID- 21665278
OWN - NLM
STAT- MEDLINE
DCOM- 20111026
LR  - 20111117
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 48
IP  - 15-16
DP  - 2011 Sep
TI  - Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis 
      patients.
PG  - 1896-902
LID - 10.1016/j.molimm.2011.05.018 [doi]
AB  - Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic 
      activity of natural killer and certain T cells through interactions with human 
      leukocyte antigen (HLA) class I ligands. KIRs have been shown to contribute to 
      the pathogenesis of several autoimmune diseases, but their role in multiple 
      sclerosis (MS) is still unclear. Here we determined the influence of KIR genes 
      and their HLA class I ligands on susceptibility to MS and on the response to 
      interferon-beta treatment in a Spanish population. KIR and HLA genotyping were 
      performed in 200 MS patients and 200 controls. Significantly higher frequencies 
      were found for KIR2DL5 and KIR3DS1 genes in MS patients and the carriage of the 
      KIR2DL1 gene was associated with a higher progression index. Moreover, the 
      frequency of the HLA-Bw4 motif was significantly reduced in MS patients. The 
      KIR2DL1 and HLA-C2 matches were more frequent in MS patients, whereas the KIR3DL1 
      and HLA-Bw4 matches were more frequent in healthy controls. Nevertheless, non 
      significant associations were found between all the KIR genes and therapeutic 
      response to interferon-beta. Our results confirm that the carriage of HLA-Bw4 is 
      a protective factor in MS and suggest that KIR2DL5 and KIR3DS1 may have a 
      predisposing role in the disease.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Garcia-Leon, Juan A
AU  - Garcia-Leon JA
AD  - Research Laboratory, Clinical Neurosciences Institute, Carlos Haya Regional 
      University Hospital and Fundacion IMABIS, Hospital Civil, Pab. 5, Sotano, 29009 
      Malaga, Spain.
FAU - Pinto-Medel, Maria J
AU  - Pinto-Medel MJ
FAU - Garcia-Trujillo, Lucia
AU  - Garcia-Trujillo L
FAU - Lopez-Gomez, Carlos
AU  - Lopez-Gomez C
FAU - Oliver-Martos, Begona
AU  - Oliver-Martos B
FAU - Prat-Arrojo, Isidro
AU  - Prat-Arrojo I
FAU - Marin-Banasco, Carmen
AU  - Marin-Banasco C
FAU - Suardiaz-Garcia, Margarita
AU  - Suardiaz-Garcia M
FAU - Maldonado-Sanchez, Rafael
AU  - Maldonado-Sanchez R
FAU - Fernandez-Fernandez, Oscar
AU  - Fernandez-Fernandez O
FAU - Leyva-Fernandez, Laura
AU  - Leyva-Fernandez L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110612
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (Immunologic Factors)
RN  - 0 (Receptors, KIR)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B Antigens/*genetics/immunology
MH  - Humans
MH  - Immunologic Factors/therapeutic use
MH  - Interferon-beta/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/drug therapy/*genetics/immunology
MH  - Polymerase Chain Reaction
MH  - Receptors, KIR/*genetics/immunology
MH  - Spain
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2011/10/27 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/04/05 00:00 [received]
PHST- 2011/05/05 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/27 06:00 [medline]
AID - S0161-5890(11)00182-9 [pii]
AID - 10.1016/j.molimm.2011.05.018 [doi]
PST - ppublish
SO  - Mol Immunol. 2011 Sep;48(15-16):1896-902. doi: 10.1016/j.molimm.2011.05.018. Epub 
      2011 Jun 12.