PMID- 21666519
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20110615
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 22
IP  - 10
DP  - 2011 Jul 13
TI  - Age-related changes in short-interval intracortical facilitation and dexterity.
PG  - 499-503
LID - 10.1097/WNR.0b013e3283487480 [doi]
AB  - Functional changes in the primary motor cortex might contribute to age-related 
      decline in fine motor control. We measured short-interval intracortical 
      facilitation (SICF) in an intrinsic hand muscle with paired-pulse transcranial 
      magnetic stimulation at interstimulus intervals (ISIs) of 1.5, 2.5, and 4.5 ms in 
      young and old participants and examined its association with dexterity. We found 
      age-related effects in SICF, with greater facilitation in old than young 
      participants at the 1.5-ms ISI and greater facilitation in young than old 
      participants at the 2.5-ms ISI. SICF at the 2.5-ms ISI was positively correlated 
      with performance on a task that required coordinated and dextrous use of both 
      hands, suggesting that this measure indicates a capacity for executing demanding 
      manual tasks.
FAU - Clark, Jordana
AU  - Clark J
AD  - School of Psychology, The University of Western Australia, Crawley.
FAU - Loftus, Andrea
AU  - Loftus A
FAU - Hammond, Geoff
AU  - Hammond G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Electric Stimulation/methods
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality
MH  - Hand/innervation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Psychomotor Performance/*physiology
MH  - Reaction Time/*physiology
MH  - Regression Analysis
MH  - Time Factors
MH  - Transcranial Magnetic Stimulation/methods
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1097/WNR.0b013e3283487480 [doi]
PST - ppublish
SO  - Neuroreport. 2011 Jul 13;22(10):499-503. doi: 10.1097/WNR.0b013e3283487480.