PMID- 21667114
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20211020
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 32
IP  - 5
DP  - 2011 Sep
TI  - [Tropheryma whipplei infection. Colonization, self-limiting infection and 
      Whipple's disease].
PG  - 362-70
LID - 10.1007/s00292-011-1446-y [doi]
AB  - Whipple's disease is a multisystemic infection caused by the ubiquitous bacterium 
      Tropheryma whipplei. Immunological host factors enable classical Whipple's 
      disease; however, T. whipplei can be found in three other clinical conditions: 
      healthy colonization, self-limiting infections, and isolated endocarditis. The 
      genetic predisposition of the host rather than the genotype of the bacterium 
      influences the infection. Modern diagnostic methods elucidate the many facets of 
      Whipple's disease. In particular, isolated T. whipplei-induced infective 
      endocarditis can only be diagnosed after valve resection. The sole treatment of 
      Whipple's disease evaluated prospectively comprises intravenous induction therapy 
      with ceftriaxone or meropenem, followed by continuation therapy with oral 
      TMP-SMX. In the case of Immune reconstitution inflammatory syndrome (IRIS) or 
      inflammatory lesions of the CNS in the setting of Whipple's disease, additional 
      treatment with corticosteroids should be considered to avoid severe tissue 
      damage.
FAU - Moos, V
AU  - Moos V
AD  - Medizinische Klinik I, Charite-Universitatsmedizin Berlin, Campus Benjamin 
      Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland. verena.moos@charite.de
FAU - Loddenkemper, C
AU  - Loddenkemper C
FAU - Schneider, T
AU  - Schneider T
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Infektionen mit Tropheryma whipplei. Besiedlung, selbstlimitierte Infektion und 
      Morbus Whipple.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Thienamycins)
RN  - 75J73V1629 (Ceftriaxone)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
RN  - FV9J3JU8B1 (Meropenem)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Algorithms
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Biopsy
MH  - Carrier State
MH  - Ceftriaxone/therapeutic use
MH  - Central Nervous System Diseases/pathology
MH  - Child
MH  - Diagnosis, Differential
MH  - Drug Therapy, Combination
MH  - Duodenum/pathology
MH  - Endocarditis, Bacterial/genetics/pathology
MH  - Gastroscopy
MH  - Genetic Predisposition to Disease/genetics
MH  - Heart Valves/pathology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/pathology
MH  - Meropenem
MH  - Thienamycins/therapeutic use
MH  - Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
MH  - *Tropheryma
MH  - Whipple Disease/drug therapy/genetics/*pathology
EDAT- 2011/06/15 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 10.1007/s00292-011-1446-y [doi]
PST - ppublish
SO  - Pathologe. 2011 Sep;32(5):362-70. doi: 10.1007/s00292-011-1446-y.