PMID- 21668080
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20211020
IS  - 1939-1846 (Electronic)
IS  - 0021-843X (Print)
IS  - 0021-843X (Linking)
VI  - 121
IP  - 1
DP  - 2012 Feb
TI  - Progression along the bipolar spectrum: a longitudinal study of predictors of 
      conversion from bipolar spectrum conditions to bipolar I and II disorders.
PG  - 16-27
LID - 10.1037/a0023973 [doi]
AB  - Little longitudinal research has examined progression to more severe bipolar 
      disorders in individuals with "soft" bipolar spectrum conditions. We examine 
      rates and predictors of progression to bipolar I and II diagnoses in a nonpatient 
      sample of college-age participants (n = 201) with high General Behavior Inventory 
      scores and childhood or adolescent onset of "soft" bipolar spectrum disorders 
      followed longitudinally for 4.5 years from the Longitudinal Investigation of 
      Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or 
      bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a 
      bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 
      individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I 
      diagnosis. Consistent with hypotheses derived from the clinical literature and 
      the Behavioral Approach System (BAS) model of bipolar disorder, and controlling 
      for relevant variables (length of follow-up, initial depressive and hypomanic 
      symptoms, treatment-seeking, and family history), high BAS sensitivity 
      (especially BAS Fun Seeking) predicted a greater likelihood of progression to 
      bipolar II disorder, whereas early age of onset and high impulsivity predicted a 
      greater likelihood of progression to bipolar I (high BAS sensitivity and 
      Fun-Seeking also predicted progression to bipolar I when family history was not 
      controlled). The interaction of high BAS and high Behavioral Inhibition System 
      (BIS) sensitivities also predicted greater likelihood of progression to bipolar 
      I. We discuss implications of the findings for the bipolar spectrum concept, the 
      BAS model of bipolar disorder, and early intervention efforts.
CI  - PsycINFO Database Record (c) 2012 APA, all rights reserved.
FAU - Alloy, Lauren B
AU  - Alloy LB
AD  - Department of Psychology, Temple University, Philadelphia, PA 19122, USA. 
      lalloy@temple.edu
FAU - Urosevic, Snezana
AU  - Urosevic S
FAU - Abramson, Lyn Y
AU  - Abramson LY
FAU - Jager-Hyman, Shari
AU  - Jager-Hyman S
FAU - Nusslock, Robin
AU  - Nusslock R
FAU - Whitehouse, Wayne G
AU  - Whitehouse WG
FAU - Hogan, Michael
AU  - Hogan M
LA  - eng
GR  - R01 MH052617/MH/NIMH NIH HHS/United States
GR  - R10 MH052662/MH/NIMH NIH HHS/United States
GR  - R01 MH052662-06A1/MH/NIMH NIH HHS/United States
GR  - MH52617/MH/NIMH NIH HHS/United States
GR  - MH77908/MH/NIMH NIH HHS/United States
GR  - R01 MH077908/MH/NIMH NIH HHS/United States
GR  - MH52662/MH/NIMH NIH HHS/United States
GR  - R01 MH052662/MH/NIMH NIH HHS/United States
GR  - R01 MH052617-07/MH/NIMH NIH HHS/United States
GR  - R10 MH052617/MH/NIMH NIH HHS/United States
GR  - R01 MH077908-04/MH/NIMH NIH HHS/United States
GR  - R01 MH077908-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110613
PL  - United States
TA  - J Abnorm Psychol
JT  - Journal of abnormal psychology
JID - 0034461
SB  - IM
MH  - Age of Onset
MH  - Bipolar Disorder/diagnosis/*psychology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Impulsive Behavior/psychology
MH  - Inhibition, Psychological
MH  - Longitudinal Studies
MH  - Male
MH  - Models, Psychological
MH  - Motivation
MH  - Predictive Value of Tests
MH  - Young Adult
PMC - PMC3192298
MID - NIHMS303445
EDAT- 2011/06/15 06:00
MHDA- 2012/04/26 06:00
PMCR- 2012/02/15
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
PHST- 2012/02/15 00:00 [pmc-release]
AID - 2011-11840-001 [pii]
AID - 10.1037/a0023973 [doi]
PST - ppublish
SO  - J Abnorm Psychol. 2012 Feb;121(1):16-27. doi: 10.1037/a0023973. Epub 2011 Jun 13.