PMID- 21668471
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110720
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jul
TI  - Invasive mammary carcinoma with neuroendocrine differentiation: histological 
      features and diagnostic challenges.
PG  - 106-15
LID - 10.1111/j.1365-2559.2011.03880.x [doi]
AB  - AIMS: The aim of this study was to review the histomorphological features of 
      primary neuroendocrine carcinomas (NEC) of the breast, in order to identify 
      features useful in recognition of this entity for appropriate classification. 
      METHODS AND RESULTS: 2003 World Health Organization (WHO) classification of 
      tumors of the breast and female genital organs defined NEC of the breast as a 
      subtype of invasive mammary carcinoma in which >50% of the tumor cells express 
      neuroendocrine markers. Seventy-four cases that fulfilled the WHO diagnostic 
      criteria for NEC of the breast, excluding small cell carcinoma and low-grade 
      solid papillary carcinoma with a predominant in-situ component, were identified 
      between 1984 and 2008 from MD Anderson Cancer Center, and were included in the 
      study. NECs of the breast had variable histomorphological features. The most 
      common histologic patterns were papillary (80%) and nested (64%). Mixed growth 
      patterns were common (59%), including admixed ductal component. The tumor cells 
      could be polygonal, round, plasmacytoid, spindled, or with signet ring cell 
      features. The cytoplasm could be granular, eosinophilic, clear, or finely 
      vacuolated. These tumors frequently mimicked invasive or in situ ductal 
      carcinoma, or invasive lobular carcinoma. CONCLUSIONS: NEC of the breast is 
      underrecognized. Careful attention to cytologic and architectural features can 
      help to identify cases that require further immunophenotypic confirmation for 
      correct tumor classification.
CI  - (c) 2011 Blackwell Publishing Limited.
FAU - Tang, Feng
AU  - Tang F
AD  - Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Wei, Bing
AU  - Wei B
FAU - Tian, Zhen
AU  - Tian Z
FAU - Gilcrease, Michael Z
AU  - Gilcrease MZ
FAU - Huo, Lei
AU  - Huo L
FAU - Albarracin, Constance T
AU  - Albarracin CT
FAU - Resetkova, Erika
AU  - Resetkova E
FAU - Zhang, Hong
AU  - Zhang H
FAU - Sahin, Aysegul
AU  - Sahin A
FAU - Chen, Jieqing
AU  - Chen J
FAU - Bu, Hong
AU  - Bu H
FAU - Abraham, Susan
AU  - Abraham S
FAU - Wu, Yun
AU  - Wu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (CHGA protein, human)
RN  - 0 (Chromogranin A)
RN  - 0 (Synaptophysin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnosis/metabolism/pathology
MH  - Carcinoma, Neuroendocrine/*diagnosis/metabolism/pathology
MH  - Cell Differentiation
MH  - Chromogranin A/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Neoplasm Invasiveness/pathology
MH  - Retrospective Studies
MH  - Synaptophysin/metabolism
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1365-2559.2011.03880.x [doi]
PST - ppublish
SO  - Histopathology. 2011 Jul;59(1):106-15. doi: 10.1111/j.1365-2559.2011.03880.x. 
      Epub 2011 Jun 13.