PMID- 21668474
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110720
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jul
TI  - Recurrent copy number gains of ACVR1 and corresponding transcript overexpression 
      are associated with survival in head and neck squamous cell carcinomas.
PG  - 81-9
LID - 10.1111/j.1365-2559.2011.03885.x [doi]
AB  - AIMS: This study aimed to evaluate the copy number alteration on 2q24, its 
      association with ACVR1 transcript expression and the prognostic value of these 
      data in head and neck squamous cell carcinomas. METHODS AND RESULTS: Twenty-eight 
      samples of squamous cell carcinoma were evaluated by fluorescence in situ 
      hybridization (FISH) using the probes RP11-546J1 (2q24) and RP11-21P18 (internal 
      control). Significant gains at 2q24 were detected in most cases at frequencies 
      varying from 3 to 35%. ACVR1 gains and amplifications were associated with longer 
      overall survival (P = 0.022). ACVR1 mRNA expression analysis in 78 cases revealed 
      overexpression in 44% (34 of 78) of these tumours, suggesting that gene copy 
      number alterations could be involved in gene overexpression. In laryngeal 
      carcinomas, overexpression of ACVR1 mRNA levels was associated with longer 
      overall survival (P = 0.013). Multivariate analysis revealed that ACVR1 is an 
      independent prognostic marker in laryngeal carcinomas (P = 0.012, hazard ratio = 
      0.165, 95% confidence interval =0.041-0.668). CONCLUSIONS: These findings suggest 
      that copy number alterations at 2q24 can be involved in ACVR1 overexpression, 
      which is associated with longer overall survival in laryngeal carcinomas. To our 
      knowledge, this is the first report indicating the relevance of ACVR1 expression 
      in head and neck cancers.
CI  - (c) 2011 Blackwell Publishing Limited.
FAU - Ambrosio, Eliane P
AU  - Ambrosio EP
AD  - Institute of Biosciences, UNESP - Sao Paulo State University, Botucatu, Sao 
      Paulo, Brazil.
FAU - Drigo, Sandra A
AU  - Drigo SA
FAU - Bergamo, Nadia A
AU  - Bergamo NA
FAU - Rosa, Fabiola E
AU  - Rosa FE
FAU - Bertonha, Fernanda B
AU  - Bertonha FB
FAU - de Abreu, Francine B
AU  - de Abreu FB
FAU - Kowalski, Luis P
AU  - Kowalski LP
FAU - Rogatto, Silvia R
AU  - Rogatto SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - EC 2.7.11.30 (ACVR1 protein, human)
RN  - EC 2.7.11.30 (Activin Receptors, Type I)
SB  - IM
MH  - Activin Receptors, Type I/*genetics
MH  - Aged
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Female
MH  - *Gene Dosage
MH  - Head and Neck Neoplasms/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/genetics/pathology
MH  - Pharyngeal Neoplasms/genetics/pathology
MH  - Prognosis
MH  - RNA, Messenger/genetics/metabolism
MH  - RNA, Neoplasm/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Up-Regulation
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1365-2559.2011.03885.x [doi]
PST - ppublish
SO  - Histopathology. 2011 Jul;59(1):81-9. doi: 10.1111/j.1365-2559.2011.03885.x. Epub 
      2011 Jun 13.