PMID- 21668975
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 10
DP  - 2011 Jun 13
TI  - Effects of preoperative feeding with a whey protein plus carbohydrate drink on 
      the acute phase response and insulin resistance. A randomized trial.
PG  - 66
LID - 10.1186/1475-2891-10-66 [doi]
AB  - BACKGROUND: Prolonged preoperative fasting increases insulin resistance and 
      current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery. Our 
      hypothesis is that the addition of whey protein to a CHO-based drink not only 
      reduces the inflammatory response but also diminish insulin resistance. METHODS: 
      Seventeen patients scheduled to cholecystectomy or inguinal herniorraphy were 
      randomized and given 474 ml and 237 ml of water (CO group) or a drink containing 
      CHO and milk whey protein (CHO-P group) respectively, 6 and 3 hours before 
      operation. Blood samples were collected before surgery and 24 hours afterwards 
      for biochemical assays. The endpoints of the study were the insulin resistance 
      (IR), the prognostic inflammatory and nutritional index (PINI) and the C-reactive 
      protein (CRP)/albumin ratio. A 5% level for significance was established. 
      RESULTS: There were no anesthetic or postoperative complications. The 
      post-operative IR was lower in the CHO-P group when compared with the CO group 
      (2.75 +/- 0.72 vs 5.74 +/- 1.16; p = 0.03). There was no difference between the two 
      groups in relation to the PINI. The CHO-P group showed a decrease in the both CRP 
      elevation and CRP/albumin ratio (p < 0.05). The proportion of patients who showed 
      CRP/albumin ratio considered normal was significantly greater (p < 0.05) in the 
      CHO-P group (87.5%) than in the CO group (33.3%). CONCLUSIONS: Shortening the 
      pre-operative fasting using CHO and whey protein is safe and reduces insulin 
      resistance and postoperative acute phase response in elective moderate 
      operations. TRIAL REGISTRATION: ClinicalTrial.gov NCT01354249.
FAU - Perrone, Francine
AU  - Perrone F
AD  - Department of Surgery, Julio Muller University Hospital, Federal University of 
      Mato Grosso, Brazil.
FAU - da-Silva-Filho, Antonio C
AU  - da-Silva-Filho AC
FAU - Adorno, Isa F
AU  - Adorno IF
FAU - Anabuki, Nadia T
AU  - Anabuki NT
FAU - Leal, Fernando S
AU  - Leal FS
FAU - Colombo, Tariane
AU  - Colombo T
FAU - da Silva, Benedito D
AU  - da Silva BD
FAU - Dock-Nascimento, Diana B
AU  - Dock-Nascimento DB
FAU - Damiao, Aderson
AU  - Damiao A
FAU - de Aguilar-Nascimento, Jose E
AU  - de Aguilar-Nascimento JE
LA  - eng
SI  - ClinicalTrials.gov/NCT01354249
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
RN  - 0 (Albumins)
RN  - 0 (Carbohydrates)
RN  - 0 (Milk Proteins)
RN  - 0 (Whey Proteins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Reaction/*drug therapy/*pathology
MH  - Adult
MH  - Albumins/administration & dosage/analysis
MH  - C-Reactive Protein/metabolism
MH  - Carbohydrates/*administration & dosage
MH  - Double-Blind Method
MH  - Fasting
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Milk Proteins/*administration & dosage/analysis
MH  - Perioperative Care
MH  - Whey Proteins
PMC - PMC3127999
EDAT- 2011/06/15 06:00
MHDA- 2011/09/16 06:00
PMCR- 2011/06/13
CRDT- 2011/06/15 06:00
PHST- 2011/04/14 00:00 [received]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PHST- 2011/06/13 00:00 [pmc-release]
AID - 1475-2891-10-66 [pii]
AID - 10.1186/1475-2891-10-66 [doi]
PST - epublish
SO  - Nutr J. 2011 Jun 13;10:66. doi: 10.1186/1475-2891-10-66.