PMID- 21670342
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20150417
IS  - 1538-3601 (Electronic)
IS  - 0003-9950 (Linking)
VI  - 129
IP  - 6
DP  - 2011 Jun
TI  - Influence of elevated intraocular pressure on the posterior chamber-anterior 
      hyaloid membrane barrier during cataract operations.
PG  - 751-7
LID - 10.1001/archophthalmol.2011.115 [doi]
AB  - OBJECTIVE: To investigate the influence of elevated intraocular pressure on the 
      posterior chamber-anterior hyaloid membrane (PC-AHM) barrier during cataract 
      operations in ex vivo porcine eyes. METHODS: A pressure transducer was connected 
      to porcine eye anterior chambers (ACs). In experiment 1, ACs were perfused for 20 
      seconds with balanced salt solution containing 1.0-mum fluorescein beads (10 eyes 
      per bottle height: 45, 85, 145, and 285 cm). In experiment 2, 5 ophthalmic 
      viscosurgical devices with different molecular weights and sodium hyaluronate 
      concentrations were infused into the ACs (20 eyes per ophthalmic viscosurgical 
      device). After continuous curvilinear capsulorrhexis, hydrodissection was 
      performed. After both experiments, PC-AHM barrier staining was evaluated through 
      the Miyake-Apple view. RESULTS: Types of fluorescein staining patterns were 
      classified as AC, zonule of Zinn, AHM, AHM tear, and ruptured capsule. In 
      experiment 1, plateau intraocular pressure and staining type were positively 
      correlated (Spearman rank correlation; r = 0.703, P < .001). In experiment 2, 
      mean peak intraocular pressure was significantly greater in the ruptured 
      capsule-type eyes than in the AC-, zonule of Zinn-, AHM (P < .001), or 
      AHM-tear-(P = .02) type eyes, as well as in the AHM- and AHM-tear-type eyes 
      compared with the AC and zonule of Zinn type eyes (P < .001). Intraocular 
      pressure was significantly higher in eyes infused with ophthalmic viscosurgical 
      devices with a higher molecular weight or sodium hyaluronate concentration (P < 
      .05). CONCLUSIONS: Stress on the PC-AHM barrier increases as intraocular pressure 
      increases. Ophthalmic viscosurgical devices with a higher molecular weight or 
      sodium hyaluronate concentration might induce increased IOP during cataract 
      operations. CLINICAL RELEVANCE: To maintain normal PC-AHM barrier function, 
      excessive intraocular pressure should be avoided during cataract operations.
FAU - Kawasaki, Shiro
AU  - Kawasaki S
AD  - Departments of Ophthalmology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-City, Ehime, Japan.
FAU - Tasaka, Yoshitaka
AU  - Tasaka Y
FAU - Suzuki, Takashi
AU  - Suzuki T
FAU - Zheng, Xiaodong
AU  - Zheng X
FAU - Shiraishi, Atsushi
AU  - Shiraishi A
FAU - Uno, Toshihiko
AU  - Uno T
FAU - Ohashi, Yuichi
AU  - Ohashi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
SB  - IM
MH  - Animals
MH  - *Blood-Aqueous Barrier
MH  - Cataract/metabolism/pathology/*physiopathology
MH  - *Cataract Extraction
MH  - Disease Models, Animal
MH  - Intraocular Pressure/*physiology
MH  - Intraoperative Period
MH  - Membranes/metabolism/*pathology
MH  - Posterior Eye Segment/metabolism/*pathology
MH  - Swine
EDAT- 2011/06/15 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 129/6/751 [pii]
AID - 10.1001/archophthalmol.2011.115 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2011 Jun;129(6):751-7. doi: 10.1001/archophthalmol.2011.115.