PMID- 21671170
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20211020
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Jun
TI  - Variation of serum monocyte chemoattractant protein-1 in patients with diabetes 
      and metabolic syndrome.
PG  - 312-316
LID - 10.1007/s11596-011-0373-8 [doi]
AB  - This study investigated the variation of serum monocyte chemoattractant protein-1 
      (MCP-1) in patients with both diabetes mellitus (DM) and metabolic syndrome (MS). 
      Based on the International Diabetes Federation (IDF) diagnostic criteria, 93 
      patients enrolled in this study were divided into four groups: normal control 
      (NC), simple DM, simple MS, and DM plus MS (DM-MS) groups. The main measures 
      included height, weight, waist circumference (WC), hip circumference, blood 
      pressure, fasting blood glucose, insulin resistance index (HOMA-IR), serum 
      triglyceride (TG), HDL-ch, LDL-ch, and MCP-1. The results showed that the serum 
      levels of MCP-1 in the DM-MS group were significantly increased as compared with 
      those in the DM and MS groups (P<0.05), and the increase in the MCP-1 level in 
      the DM group was much higher than in the MS group (P<0.05). The DM-MS group had 
      the highest HOMA-IR levels, followed by MS, DM and NC groups (P<0.05). 
      Correlation tests showed that the association of MCP-1 with age, HDL-ch, or 
      LDL-ch was insignificant, whereas that of MCP-1 with body mass index (BMI), waist 
      hip rate (WHR), WC, systolic blood pressure (SBP), diastolic blood pressure 
      (DBP), TG, and HOMA-IR was significantly positive. It was concluded that 
      circulating MCP-1 was substantially increased in patients with both DM and MS as 
      compared with that in the patients with DM or MS alone, and the central obese 
      state may contribute to a more vicious proinflammatory condition and insulin 
      resistance in patients with diabetes.
FAU - Li, Huiqing
AU  - Li H
AD  - Department of Endocrinology, Huazhong University of Science and Technology, 
      Wuhan, 430022, China.
FAU - Deng, Xiuling
AU  - Deng X
AD  - Department of Endocrinology, Huazhong University of Science and Technology, 
      Wuhan, 430022, China.
FAU - Li, Zhenqiong
AU  - Li Z
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Luo, Changqing
AU  - Luo C
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Liu, Jianshe
AU  - Liu J
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Wang, Yumei
AU  - Wang Y
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. 
      wangyumei75@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110614
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Inflammation/etiology
MH  - *Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/*blood/complications
MH  - Middle Aged
MH  - Obesity, Abdominal/complications
EDAT- 2011/06/15 06:00
MHDA- 2013/05/03 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1007/s11596-011-0373-8 [pii]
AID - 10.1007/s11596-011-0373-8 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2011 Jun;31(3):312-316. doi: 
      10.1007/s11596-011-0373-8. Epub 2011 Jun 14.