PMID- 21671709
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20120113
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 117
IP  - 3
DP  - 2011 Jul
TI  - Mitochondrial pathophysiology and type 2 diabetes mellitus.
PG  - 177-87
LID - 10.3109/13813455.2011.584538 [doi]
AB  - Over the last decades, substantial progress has been made in defining the 
      molecular events and relevant tissues controlling insulin action and the 
      potential defects that lead to insulin resistance and later on Type 2 diabetes 
      mellitus (T2DM). Mitochondrial dysfunction has been postulated as a common 
      mechanism implicated in the development of insulin resistance and T2DM aetiology. 
      Since then there has been growing interest in this area of research and many 
      studies have addressed whether mitochondrial function/dysfunction is implicated 
      in the progression of T2DM or if it is just a consequence. Mitochondria are 
      adjusted to the specific needs of the tissue and to the environmental 
      interactions or pathophysiological state that it encounters. This review offers a 
      current state of the subject in a tissue specific approach. We will focus our 
      attention on skeletal muscle, liver, and white adipose tissue as the main insulin 
      sensitive organs. Hypothalamic mitochondrial function will be also discussed.
FAU - Garcia-Roves, Pablo M
AU  - Garcia-Roves PM
AD  - Diabetes and Obesity Laboratory, Institute for Biomedical Research August Pi i 
      Sunyer (IDIBAPS) and Spanish Biomedical Research Centre in Diabetes and 
      Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain. 
      pgarciar@clinic.ub.es
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PT  - Review
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Insulin)
SB  - IM
RIN - Arch Physiol Biochem. 2011 Dec;117(5):283. PMID: 22080829
MH  - Adipose Tissue, White/metabolism/physiopathology
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Energy Metabolism
MH  - Humans
MH  - Hypothalamus/metabolism/physiopathology
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Liver/metabolism/physiopathology
MH  - Mitochondria/*physiology
MH  - Muscle, Skeletal/metabolism/physiopathology
EDAT- 2011/06/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.3109/13813455.2011.584538 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2011 Jul;117(3):177-87. doi: 10.3109/13813455.2011.584538.