PMID- 21671754
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20220129
IS  - 1557-7716 (Electronic)
IS  - 1523-0864 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Aug 1
TI  - The oxidative folding and misfolding of human leukocyte antigen-b27.
PG  - 669-84
LID - 10.1089/ars.2010.3692 [doi]
AB  - The major histocompatibility complex class I molecule human leukocyte antigen 
      (HLA)-B27 is strongly associated with a group of inflammatory arthritic disorders 
      known as the spondyloarthropathies. Many autoimmune diseases exhibit associations 
      with major histocompatibility complex molecules encoded within the class II locus 
      with defined immune responses either mediated by T or B-lymphocytes. Despite the 
      association being known for over 30 years, no defined immune response and target 
      autoantigens have been characterized for the spondyloarthropathies. Thus, the 
      mechanism and role of HLA-B27 in disease pathogenesis remains undetermined. One 
      hypothesis that has recently received much attention has focused around the 
      enhanced propensity for HLA-B27 to misfold and the increased tendency of the 
      heavy chain to dimerize. The misfolding of HLA-B27 has been associated with its 
      redox status and this is postulated to be involved in disease development. Here 
      we discuss the impact of the redox status on HLA-B27 biosynthesis and function.
FAU - Antoniou, Antony N
AU  - Antoniou AN
AD  - Division of Infection and Immunity/Centre of Rheumatology, Department of 
      Immunology and Molecular Pathology, University College London, Windeyer Institute 
      of Medical Science, London, United Kingdom. anthony.antoniou@ucl.ac.uk
FAU - Guiliano, David B
AU  - Guiliano DB
FAU - Lenart, Izabela
AU  - Lenart I
FAU - Burn, Garth
AU  - Burn G
FAU - Powis, Simon J
AU  - Powis SJ
LA  - eng
GR  - 18440/ARC_/Arthritis Research UK/United Kingdom
GR  - 18440/VAC_/Versus Arthritis/United Kingdom
GR  - 17222/ARC_/Arthritis Research UK/United Kingdom
GR  - 15293/ARC_/Arthritis Research UK/United Kingdom
GR  - 17868/ARC_/Arthritis Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110614
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (Disulfides)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (beta 2-Microglobulin)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Cysteine/chemistry
MH  - Disulfides/chemistry
MH  - HLA-B27 Antigen/chemistry/*metabolism
MH  - Histocompatibility Antigens Class II/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Lymphocytes/immunology
MH  - Oxidation-Reduction
MH  - Oxidative Stress/immunology
MH  - Protein Folding
MH  - Protein Multimerization/immunology
MH  - Proteostasis Deficiencies/*metabolism
MH  - Spondylarthropathies/*metabolism
MH  - beta 2-Microglobulin/metabolism
EDAT- 2011/06/16 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.1089/ars.2010.3692 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2011 Aug 1;15(3):669-84. doi: 10.1089/ars.2010.3692. Epub 
      2011 Jun 14.