PMID- 21672354
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20170214
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 39
IP  - 2
DP  - 2011
TI  - The amount of surface HLA-I on T lymphocytes decreases in breast infiltrating 
      ductal carcinoma patients.
PG  - 508-13
AB  - Human leucocyte antigen class I (HLA-I), which includes HLA-A, -B and -C, is an 
      essential immune factor participating in the antitumour immune response. The 
      changes in HLA-I expression in peripheral blood T lymphocytes in cancer patients 
      have yet to be defined. This study examined the expression of HLA-I on CD4(+) and 
      CD8(+) T lymphocytes in female patients with stage I - IV breast infiltrating 
      ductal carcinoma, benign breast tumour diseases (mammary intraductal papilloma or 
      breast fibroadenoma), and in healthy controls. HLA-I was down-regulated on CD4(+) 
      T lymphocytes from patients with stage III and IV cancer, and on CD8(+) T 
      lymphocytes in patients with stage I - IV cancer compared with healthy controls. 
      HLA-I expression in T lymphocytes may contribute towards immune-balance disorders 
      in tumour patients.
FAU - Zhao, S
AU  - Zhao S
AD  - Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, 
      Jinan, China.
FAU - Yang, X
AU  - Yang X
FAU - Lu, N
AU  - Lu N
FAU - Zhang, Y
AU  - Zhang Y
FAU - Li, X
AU  - Li X
FAU - Li, Y
AU  - Li Y
FAU - Zhou, Y
AU  - Zhou Y
FAU - Wan, F
AU  - Wan F
FAU - Zou, X
AU  - Zou X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*immunology/pathology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Carcinoma, Ductal, Breast/*immunology/pathology
MH  - Female
MH  - Fluorescence
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Middle Aged
MH  - T-Lymphocytes/*immunology
EDAT- 2011/06/16 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1177/147323001103900218 [doi]
PST - ppublish
SO  - J Int Med Res. 2011;39(2):508-13. doi: 10.1177/147323001103900218.