PMID- 21672386
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20191210
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 23
IP  - 6
DP  - 2011 Jun
TI  - [The value of aggressive diuretic therapy in acute decompensated stage of chronic 
      heart failure].
PG  - 359-62
AB  - OBJECTIVE: To evaluate both the efficacy, safety, length of stay in hospital and 
      expenses of aggressive diuretic therapy in patients with acute decompensation of 
      chronic heart failure (CHF). METHODS: The retrospective analysis was conducted in 
      the patients with acute decompensation CHF New York Heart Association (NYHA) 
      class III or IV in department of cardiology of Fujian Medical University Union 
      Hospital from January 1st 2006 to September 1st 2007. The 24-hour urine volume on 
      the 2nd day was equivalent or over 2 400 ml was defined as aggressive diuretic 
      therapy group, and those with less than 2 400 ml of urine as non-aggressive 
      diuretic therapy group. The biochemical parameters and vital signs were compared 
      before and after aggressive diuretic therapy, and the mortality, the length of 
      stay and expenses were also compared between the two groups. RESULTS: One hundred 
      and ninety-five patients were enrolled in the study, there were 73 and 122 
      patients in aggressive diuretic therapy group and in non-aggressive diuretic 
      therapy group respectively. The mortality in aggressive diuretic therapy group 
      was lower than that in non-aggressive diuretic therapy group (1.4% vs. 9.8%, 
      P<0.05). The length of stay, total expenses and average cost in aggressive 
      diuretic therapy group were lower than those in non-aggressive diuretic therapy 
      group respectively [the length of stay: 11 days vs. 16 days; total expenses: 8 
      483 yuan vs. 12 182 yuan; average expenseI: 721.1 yuan/d vs. 854.4 yuan/d; 
      average expenseII (except for examination expenses): 580.0 yuan/d vs. 698.2 
      yuan/d, P<0.05 or P<0.01]. There were no significant changes in biochemical 
      parameters and heart rate before and after aggressive diuretic therapy. The 
      systolic pressure (SBP) and diastolic pressure (DBP) were reduced significantly 
      after aggressive diuretic therapy [SBP: (118.2+/-16.9) mm Hg vs. (127.0+/-24.9) mm 
      Hg; DBP: (67.2+/-4.5) mm Hg vs. (75.2+/-4.9) mm Hg, 1 mm Hg=0.133 kPa, P<0.05 and 
      P<0.01]. No hypotension symptoms such as dizziness and chest distress were found 
      in all patients. CONCLUSION: Aggressive diuretic therapy in patients with acute 
      decompensation CHF is a safe, effective mode of therapy. It can reduce the length 
      of stay in hospital, expenses and the mortality during hospitalization.
FAU - Li, Jia-bin
AU  - Li JB
AD  - Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou 
      350001, Fujian, China.
FAU - Hong, Hua-shan
AU  - Hong HS
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
RN  - 0 (Diuretics)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Diuretics/*therapeutic use
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Retrospective Studies
EDAT- 2011/06/16 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Jun;23(6):359-62.