PMID- 21672534
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20220408
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 412
IP  - 19-20
DP  - 2011 Sep 18
TI  - Reference intervals for serum creatinine with enzymatic assay and evaluation of 
      four equations to estimate glomerular filtration rate in a healthy Chinese adult 
      population.
PG  - 1793-7
LID - 10.1016/j.cca.2011.05.033 [doi]
AB  - BACKGROUND: With the wide usage of enzymatic assays to determine serum creatinine 
      (Scr) in China, reference interval (RI) needs to be established. At the same 
      time, the performance of Scr based equations to calculate estimated glomerular 
      filtration rate (eGFR) in healthy Chinese adults has not been extensively 
      investigated. METHODS: This study has strictly followed the International 
      Federation of Clinical Chemistry (IFCC) recommendations and the Clinical 
      Laboratory Standards Institute (CLSI) C28-A2 document. A total number of 778 
      healthy Chinese adults (male 433, female 345) were enrolled in this study. 
      RESULTS: By nonparametric method, RIs for males were: <60 years, 58-93 mumol/l and 
      >60 years, 54-109 mumol/l; RIs for females were: <60 years, 42-69 mumol/l and >60 
      years, 43-83 mumol/l. Modification of Diet in Renal Disease (MDRD) equation and 
      MDRD for Japanese made the percentage of eGFR >90 ml/min/1.73 m(2) 31.7% and 
      4.9%; percentage of eGFR 60-89 ml/min/1.73 m(2) 65.2% and 64.0%, respectively. 
      Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD-EPI 
      for Asian made the percentage of eGFR >90 ml/min/1.73 m(2) 89.2% and 94.0%; 
      percentage of eGFR 60-89 ml/min/1.73 m(2) 10.3% and 5.7%, respectively. 
      CONCLUSION: Scr RIs of healthy Chinese adults were found to be lower than those 
      of Caucasians. Two MDRD equations underestimated GFR, while two CKD-EPI equations 
      seemed to estimate a reasonable distribution of eGFR in healthy Chinese adult 
      populations.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Wang, XueJing
AU  - Wang X
AD  - Department of Clinical Laboratory, Peking University First Hospital, Beijing, 
      China.
FAU - Xu, GuoBin
AU  - Xu G
FAU - Li, HaiXia
AU  - Li H
FAU - Liu, Yan
AU  - Liu Y
FAU - Wang, Fang
AU  - Wang F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - Creatinine/*blood/standards
MH  - *Enzyme Assays
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Reproducibility of Results
EDAT- 2011/06/16 06:00
MHDA- 2012/08/10 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/01/22 00:00 [received]
PHST- 2011/05/30 00:00 [revised]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - S0009-8981(11)00308-1 [pii]
AID - 10.1016/j.cca.2011.05.033 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2011 Sep 18;412(19-20):1793-7. doi: 10.1016/j.cca.2011.05.033. 
      Epub 2011 Jun 7.