PMID- 21673408
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20110921
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 26
IP  - 3
DP  - 2011
TI  - Study of estrogen receptor-alpha and receptor-beta gene polymorphisms on Alzheimer's 
      disease.
PG  - 431-9
LID - 10.3233/JAD-2011-110362 [doi]
AB  - Estrogen treatment can modulate the risk for developing dementia in women. 
      Therefore, single nucleotide polymorphisms (SNPs) in the estrogen receptor genes 
      may constitute genetic susceptibility factors to Alzheimer's disease (AD). Thus, 
      we investigated the impact of the genetic variability of the estrogen receptor alpha 
      1 (ESR1) and estrogen receptor alpha 2 (ESR2) genes on late onset AD risk. We 
      analyzed 39 SNPs in ESR1 and 5 SNPs in ESR2 in a French case-control study of 
      sporadic AD (1007 cases/647 controls). Individuals carrying the minor allele of 
      rs7450824 had a lower risk of AD than homozygous subjects for the major allele 
      (age, gender, and APOE epsilon4 allele adjusted odds ratio = 0.71 [0.57-0.89], p = 
      0.003). However, this association did not resist Bonferroni correction for 
      multiple testing (p-threshold < 0.001). Consistently, no significant association 
      could be detected when considering age of onset. We also tested for possible 
      interactions between the ESR SNPs and APOE status (epsilon4 allele) or gender but no 
      significant interaction could be observed. Even after stratifying the sample on 
      APOE status or gender, no significant association with AD risk could be detected. 
      Finally, we searched for potential gene-gene interactions between ESR1 and ESR2 
      SNPs but no significant interaction could be detected. Our results reinforce the 
      notion that SNPs in the ESR1 or ESR2 genes do not seem to play a major role in 
      the genetic susceptibility of AD.
FAU - Goumidi, Louisa
AU  - Goumidi L
AD  - INSERM, U744; Institut Pasteur de Lille; Univ Lille Nord de France; UDSL, Lille, 
      France.
FAU - Dahlman-Wright, Karin
AU  - Dahlman-Wright K
FAU - Tapia-Paez, Isabel
AU  - Tapia-Paez I
FAU - Matsson, Hans
AU  - Matsson H
FAU - Pasquier, Florence
AU  - Pasquier F
FAU - Amouyel, Philippe
AU  - Amouyel P
FAU - Kere, Juha
AU  - Kere J
FAU - Lambert, Jean-Charles
AU  - Lambert JC
FAU - Meirhaeghe, Aline
AU  - Meirhaeghe A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoproteins E)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*genetics
MH  - Apolipoproteins E/genetics
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Estrogen Receptor beta/*genetics
MH  - Female
MH  - Genes, Dominant
MH  - Genes, Recessive
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Risk Assessment
EDAT- 2011/06/16 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - M4612RU130R7225U [pii]
AID - 10.3233/JAD-2011-110362 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2011;26(3):431-9. doi: 10.3233/JAD-2011-110362.