PMID- 2167462
OWN - NLM
STAT- MEDLINE
DCOM- 19900927
LR  - 20110726
IS  - 0048-0428 (Print)
IS  - 0048-0428 (Linking)
VI  - 50
IP  - 4
DP  - 1990 Apr 25
TI  - [Late radiation fibrosis in rat lung following protons and 250 kV X-rays 
      irradiation].
PG  - 412-22
AB  - To investigate the biological effectiveness of proton beams in the development of 
      pulmonary fibrosis the lungs of male 7-week-old Wistar rats were locally 
      irradiated with a single dose of 10-50 Gy of 250 kV X-rays and modulated, 250 MeV 
      protons at Particle Radiation Medical Science Center (PARMS). Animals were 
      sacrificed serially after 3, 6, 9 and 12 months at which times the development of 
      the fibrotic lesion in alveolar walls and peribronchial connective tissues was 
      assessed quantitatively by analysis of microscopic images of Azan-Mallory stained 
      sections. Fibrosis index (FI) values in alveolar walls and peribronchial tissues 
      were defined as the fraction (in percent) of a specific image area, the gray 
      level of which represents collagen deposits. Using this FI values, the increase 
      of fibrotic lesion following 0-40 Gy of X-rays irradiation as a function of time 
      were observed better in alveolar walls than in peribronchial tissues. Compared 
      with 250 kV X-rays, 30 Gy of proton beams irradiation produced less increase in 
      the time course of FI values of alveolar walls and dose-response curve at 12 
      months later suggested that the fibrotic lesion in alveolar walls after protons 
      exposure of the doses above 30 Gy might develop more slowly.
FAU - Murayama, S
AU  - Murayama S
AD  - Department of Radiology, School of Medicine, Osaka University.
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Igaku Hoshasen Gakkai Zasshi
JT  - Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
JID - 0413544
RN  - 0 (Protons)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Radiation
MH  - Male
MH  - Protons
MH  - Pulmonary Fibrosis/*etiology/pathology
MH  - Radiation Dosage
MH  - *Radiation Injuries, Experimental/pathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Specific Pathogen-Free Organisms
EDAT- 1990/04/25 00:00
MHDA- 1990/04/25 00:01
CRDT- 1990/04/25 00:00
PHST- 1990/04/25 00:00 [pubmed]
PHST- 1990/04/25 00:01 [medline]
PHST- 1990/04/25 00:00 [entrez]
PST - ppublish
SO  - Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Apr 25;50(4):412-22.