PMID- 21677076
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 141
IP  - 8
DP  - 2011 Aug
TI  - Whey protein but not soy protein supplementation alters body weight and 
      composition in free-living overweight and obese adults.
PG  - 1489-94
LID - 10.3945/jn.111.139840 [doi]
AB  - A double-blind, randomized clinical trial was conducted to determine the effect 
      of consumption of supplemental whey protein (WP), soy protein (SP), and an 
      isoenergetic amount of carbohydrate (CHO) on body weight and composition in 
      free-living overweight and obese but otherwise healthy participants. Ninety 
      overweight and obese participants were randomly assigned to 1 of 3 treatment 
      groups for 23 wk: 1) WP; 2) SP (each providing ~56 g/d of protein and 1670 kJ/d); 
      or 3) an isoenergetic amount of CHO. Supplements were consumed as a beverage 
      twice daily. Participants were provided no dietary advice and continued to 
      consume their free-choice diets. Participants' body weight and composition data 
      were obtained monthly. Dietary intake was determined by 24-h dietary recalls 
      collected every 10 d. After 23 wk, body weight and composition did not differ 
      between the groups consuming the SP and WP or between SP and CHO; however, body 
      weight and fat mass of the group consuming the WP were lower by 1.8 kg (P < 
      0.006) and 2.3 kg (P < 0.005), respectively, than the group consuming CHO. Lean 
      body mass did not differ among any of the groups. Waist circumference was smaller 
      in the participants consuming WP than in the other groups (P < 0.05). Fasting 
      ghrelin was lower in participants consuming WP compared with SP or CHO. Through 
      yet-unknown mechanisms, different sources of dietary protein may differentially 
      facilitate weight loss and affect body composition. Dietary recommendations, 
      especially those that emphasize the role of dietary protein in facilitating 
      weight change, should also address the demonstrated clinical potential of 
      supplemental WP.
FAU - Baer, David J
AU  - Baer DJ
AD  - Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, 
      Beltsville, MD 20705, USA. david.baer@ars.usda.gov
FAU - Stote, Kim S
AU  - Stote KS
FAU - Paul, David R
AU  - Paul DR
FAU - Harris, G Keith
AU  - Harris GK
FAU - Rumpler, William V
AU  - Rumpler WV
FAU - Clevidence, Beverly A
AU  - Clevidence BA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110615
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Milk Proteins)
RN  - 0 (Soybean Proteins)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - *Body Composition
MH  - *Body Weight
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Milk Proteins/*administration & dosage
MH  - Obesity/*physiopathology
MH  - Overweight/*physiopathology
MH  - Soybean Proteins/*administration & dosage
MH  - Whey Proteins
PMC - PMC3145217
COIS- Author disclosures: D. J. Baer, K. S. Stote, D. R. Paul, G. K. Harris, W. V. 
      Rumpler, B. A. Clevidence, no conflicts of interest.
EDAT- 2011/06/17 06:00
MHDA- 2011/09/22 06:00
PMCR- 2011/06/15
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
PHST- 2011/06/15 00:00 [pmc-release]
AID - S0022-3166(22)03032-2 [pii]
AID - 139840 [pii]
AID - 10.3945/jn.111.139840 [doi]
PST - ppublish
SO  - J Nutr. 2011 Aug;141(8):1489-94. doi: 10.3945/jn.111.139840. Epub 2011 Jun 15.