PMID- 21677158
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 31
IP  - 24
DP  - 2011 Jun 15
TI  - Perirhinal and parahippocampal cortices differentially contribute to later 
      recollection of object- and scene-related event details.
PG  - 8739-47
LID - 10.1523/JNEUROSCI.4978-10.2011 [doi]
AB  - How the different elements of our experiences are encoded into episodic memories 
      has remained one of the major questions in memory research. Although the pivotal 
      role of the medial temporal lobe as a whole for memory formation is well 
      established, much controversy surrounds the precise contributions of the 
      subregions in the medial temporal lobe cortex (MTLC), most notably the perirhinal 
      cortex (PrC) and the parahippocampal cortex (PhC). Although one prominent view 
      links PrC processes with familiarity-based memory and PhC with recollection, an 
      alternative organizing principle is the representational domain critical for 
      successful memory performance (e.g., object- versus scene-related information). 
      In this functional magnetic resonance imaging study, we directly compared 
      successful source encoding during object versus scene imagery, holding perceptual 
      input constant across the two representational domains. Although the hippocampus 
      contributed to associative encoding of both object and scene information, our 
      results revealed a clear double dissociation between PrC and PhC for object- 
      versus scene-related source encoding. In particular, PrC, but not PhC, encoding 
      activation predicted later source memory for the object imagery task, whereas 
      PhC, but not PrC, encoding activation predicted later source memory for the scene 
      imagery task. Interestingly, the transitional zone between PrC and posterior PhC 
      contributed to both object and scene source encoding, possibly reflecting a 
      gradient in domain preference along MTLC. In sum, these results strongly point to 
      representational domain as a key factor determining the involvement of different 
      MTLC subregions during successful episodic memory formation.
FAU - Staresina, Bernhard P
AU  - Staresina BP
AD  - Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 7EF, 
      United Kingdom. bernhard.staresina@mrc-cbu.cam.ac.uk
FAU - Duncan, Katherine D
AU  - Duncan KD
FAU - Davachi, Lila
AU  - Davachi L
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 089049/Wellcome Trust/United Kingdom
GR  - R01 MH074692/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Brain Mapping
MH  - Discrimination, Psychological
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imagination/*physiology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Mental Recall/*physiology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Reaction Time
MH  - Recognition, Psychology
MH  - Temporal Lobe/blood supply/*physiology
MH  - Young Adult
PMC - PMC3128497
MID - UKMS35728
OID - NLM: UKMS35728
EDAT- 2011/06/17 06:00
MHDA- 2011/08/23 06:00
PMCR- 2011/12/15
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
PHST- 2011/12/15 00:00 [pmc-release]
AID - 31/24/8739 [pii]
AID - 3688510 [pii]
AID - 10.1523/JNEUROSCI.4978-10.2011 [doi]
PST - ppublish
SO  - J Neurosci. 2011 Jun 15;31(24):8739-47. doi: 10.1523/JNEUROSCI.4978-10.2011.