PMID- 21677379 OWN - NLM STAT- MEDLINE DCOM- 20120111 LR - 20131121 IS - 1875-8908 (Electronic) IS - 1387-2877 (Linking) VI - 26 IP - 3 DP - 2011 TI - BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response. PG - 523-30 LID - 10.3233/JAD-2011-110113 [doi] AB - Brain-derived neurotrophic factor (BDNF) is needed to support neuronal survival and differentiation. It also promotes synaptic remodeling and modulates the function of many other neurotransmitters. The current study examined potential association between single nucleotide polymorphisms (SNPs) of the BDNF gene (G11757 C, C270T, G196A, G-712A) and Alzheimer's disease-related depression (AD-D). Participants included 336 patients with AD; 128 of these patients had AD-D. Response to 8-week paroxetine treatment was also assessed. The frequency of the 11757 C allele was significantly higher in AD-D than in the Alzheimer's disease without depression (AD-nD) patients (p = 0.003 after Bonferroni correction). The 196A allele occurred with significantly higher frequency in AD-D patients (p = 0.001 after Bonferroni correction versus AD-nD). Carriers of the A allele of G196A responded better to paroxetine treatment. These findings support an important role of BDNF polymorphism in AD-D. FAU - Zhang, Lu AU - Zhang L AD - Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhengzhou University, Zhengzhou, PR China. FAU - Fang, Yu AU - Fang Y FAU - Zeng, Zhaoshu AU - Zeng Z FAU - Lian, Yajun AU - Lian Y FAU - Wei, Jianke AU - Wei J FAU - Zhu, Hongcan AU - Zhu H FAU - Jia, Yanjie AU - Jia Y FAU - Zhao, Xinyu AU - Zhao X FAU - Xu, Yuming AU - Xu Y LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - J Alzheimers Dis JT - Journal of Alzheimer's disease : JAD JID - 9814863 RN - 0 (Antidepressive Agents) RN - 0 (Antidepressive Agents, Second-Generation) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 41VRH5220H (Paroxetine) SB - IM MH - Aged MH - Alleles MH - Alzheimer Disease/complications/*genetics/psychology MH - Antidepressive Agents/*therapeutic use MH - Antidepressive Agents, Second-Generation/therapeutic use MH - Brain-Derived Neurotrophic Factor/*genetics MH - Depression/*drug therapy/etiology/*genetics MH - Female MH - Genotype MH - Humans MH - Linkage Disequilibrium MH - Male MH - Paroxetine/therapeutic use MH - Polymorphism, Genetic/genetics MH - Polymorphism, Single Nucleotide MH - Psychiatric Status Rating Scales MH - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization EDAT- 2011/06/17 06:00 MHDA- 2012/01/12 06:00 CRDT- 2011/06/17 06:00 PHST- 2011/06/17 06:00 [entrez] PHST- 2011/06/17 06:00 [pubmed] PHST- 2012/01/12 06:00 [medline] AID - TQ111X5424524302 [pii] AID - 10.3233/JAD-2011-110113 [doi] PST - ppublish SO - J Alzheimers Dis. 2011;26(3):523-30. doi: 10.3233/JAD-2011-110113.