PMID- 21677425
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20151119
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 83
IP  - 3
DP  - 2012
TI  - Altered phenotype of blood dendritic cells in patients with acute pneumonia.
PG  - 209-17
LID - 10.1159/000328406 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) play a key role in the host defence against 
      inhaled pathogens. However, the phenotype of blood DCs in patients with acute 
      respiratory infections is unknown. OBJECTIVE: To investigate the number and the 
      expression of function-associated molecules of blood DCs in patients with acute 
      infectious pneumonia. METHODS: Sixteen patients with acute pneumonia and 19 
      controls without pneumonia were included in the study. The number as well as the 
      expression of function-associated molecules of myeloid DCs (mDCs) and 
      plasmacytoid DCs (pDCs) were analysed in peripheral blood using four-colour flow 
      cytometry. RESULTS: Elevated concentrations of procalcitonin (median: 0.55 ng/ml) 
      and the rapid response to antibiotic treatment suggested a bacterial origin of 
      the pneumonia in the patients. Total mDC (median: 27% of the controls) and pDC 
      counts (median: 53% of the controls) were markedly reduced in patients with 
      pneumonia, as compared to the controls. Percentages of blood mDCs, but not pDCs, 
      were negatively correlated with serum concentrations of C-reactive protein. 
      Patients with pneumonia were characterised by a significantly increased 
      expression of Fc gamma receptors (CD32 and CD64) on mDCs and the Toll-like 
      receptor 9 (TLR9) on pDCs. CONCLUSIONS: Circulating DCs are markedly reduced in 
      patients with pneumonia, and characterised by an up-regulation of molecules 
      recognising pathogen-associated molecular patterns and opsonised antigens.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Dreschler, Katharina
AU  - Dreschler K
AD  - Department of Pneumology, University of Rostock, Rostock, Germany.
FAU - Bratke, Kai
AU  - Bratke K
FAU - Petermann, Sebastian
AU  - Petermann S
FAU - Thamm, Petra
AU  - Thamm P
FAU - Kuepper, Michael
AU  - Kuepper M
FAU - Virchow, J Christian
AU  - Virchow JC
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110616
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Biomarkers)
RN  - 670-65-5 (Neopterin)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Dendritic Cells/*pathology
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Male
MH  - Middle Aged
MH  - Neopterin/blood
MH  - Phenotype
MH  - Pilot Projects
MH  - Pneumonia/blood/*immunology
MH  - Young Adult
EDAT- 2011/06/17 06:00
MHDA- 2012/06/15 06:00
CRDT- 2011/06/17 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 000328406 [pii]
AID - 10.1159/000328406 [doi]
PST - ppublish
SO  - Respiration. 2012;83(3):209-17. doi: 10.1159/000328406. Epub 2011 Jun 16.