PMID- 21677640
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110720
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 90
IP  - 2
DP  - 2011 Aug
TI  - Can network analysis improve pattern recognition among adverse events following 
      immunization reported to VAERS?
PG  - 271-8
LID - 10.1038/clpt.2011.119 [doi]
AB  - Current methods of statistical data mining are limited in their ability to 
      facilitate the identification of patterns of potential clinical interest from 
      spontaneous reporting systems of medical product adverse events (AEs). Network 
      analysis (NA) allows for simultaneous representation of complex connections among 
      the key elements of such a system. The Vaccine Adverse Event Reporting System 
      (VAERS) can be represented as a network of 6,428 nodes (74 vaccines and 6,354 
      AEs) with more than 1.4 million interlinkages. VAERS has the characteristics of a 
      "scale-free" network, with certain vaccines and AEs acting as "hubs" in the 
      network. Known safety signals were visualized using NA methods, including hub 
      identification. NA offers a complementary approach to current statistical 
      data-mining techniques for visualizing multidimensional patterns, providing a 
      structural framework for evaluating AE data.
FAU - Ball, R
AU  - Ball R
AD  - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and 
      Research, US Food and Drug Administration, Rockville, Maryland, USA.
FAU - Botsis, T
AU  - Botsis T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Vaccines)
SB  - IM
MH  - Adverse Drug Reaction Reporting Systems/*statistics & numerical data
MH  - Data Interpretation, Statistical
MH  - Data Mining/*methods
MH  - Humans
MH  - Pattern Recognition, Automated/*methods
MH  - Vaccines/*adverse effects
EDAT- 2011/06/17 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - clpt2011119 [pii]
AID - 10.1038/clpt.2011.119 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Aug;90(2):271-8. doi: 10.1038/clpt.2011.119. Epub 2011 
      Jun 15.