PMID- 21677660
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20221207
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 34
IP  - 9
DP  - 2011 Sep
TI  - Significance of measuring oxidative stress in lifestyle-related diseases from the 
      viewpoint of correlation between d-ROMs and BAP in Japanese subjects.
PG  - 1041-5
LID - 10.1038/hr.2011.76 [doi]
AB  - In recent years, oxidative stress has been postulated to be an important factor 
      in the pathogenesis and development of lifestyle-related diseases. In this study, 
      we investigated the association between the derivatives of reactive oxygen 
      metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), 
      and biological antioxidant potential (BAP), as an index of antioxidant potential. 
      We also investigated the associations between d-ROMs or BAP and the risk factors 
      for lifestyle-related diseases or metabolic syndrome-associated factors to 
      evaluate their usefulness in preventive medicine. There were 442 subjects who 
      underwent health checkup examination in our facilities. In addition to standard 
      medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave 
      velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) 
      visualized on a computed tomography scan. The mean d-ROM value in females was 
      significantly higher than that in males. There was a positive correlation between 
      the d-ROM and VFA levels. On correlation analysis, there was a negative 
      correlation between the d-ROM and creatinine levels. As factors that influence 
      d-ROMs, the level of VFA was selected, suggesting the significance of oxidative 
      stress measurement with d-ROMs. In addition, there was a positive correlation 
      between d-ROMs and BAP values. Further research is required to resolve whether 
      increased production of ROS or the antioxidant potential that can compensate for 
      such an increase of ROS is more important in vivo.
FAU - Fukui, Toshiki
AU  - Fukui T
AD  - Center for Preventive Medical Treatment, NTT West Takamatsu Hospital, Takamatsu, 
      Japan. ftoshi@kagawa.west.ntt.co.jp
FAU - Yamauchi, Kazuhiro
AU  - Yamauchi K
FAU - Maruyama, Mie
AU  - Maruyama M
FAU - Yasuda, Tadashi
AU  - Yasuda T
FAU - Kohno, Masakazu
AU  - Kohno M
FAU - Abe, Youichi
AU  - Abe Y
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism/*physiology
MH  - Asian People
MH  - Brachial Artery/physiopathology
MH  - C-Reactive Protein/analysis/physiology
MH  - Creatinine/blood
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/diagnostic imaging/physiology
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Pulsatile Flow/physiology
MH  - Radiography
MH  - Reactive Oxygen Species/*metabolism
MH  - Sex Factors
EDAT- 2011/06/17 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - hr201176 [pii]
AID - 10.1038/hr.2011.76 [doi]
PST - ppublish
SO  - Hypertens Res. 2011 Sep;34(9):1041-5. doi: 10.1038/hr.2011.76. Epub 2011 Jun 16.