PMID- 21677775
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 6
DP  - 2011
TI  - Microstructure abnormalities in adolescents with internet addiction disorder.
PG  - e20708
LID - 10.1371/journal.pone.0020708 [doi]
LID - e20708
AB  - BACKGROUND: Recent studies suggest that internet addiction disorder (IAD) is 
      associated with structural abnormalities in brain gray matter. However, few 
      studies have investigated the effects of internet addiction on the 
      microstructural integrity of major neuronal fiber pathways, and almost no studies 
      have assessed the microstructural changes with the duration of internet 
      addiction. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the morphology of the 
      brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry 
      (VBM) technique, and studied the white matter fractional anisotropy (FA) changes 
      using the diffusion tensor imaging (DTI) method, linking these brain structural 
      measures to the duration of IAD. We provided evidences demonstrating the multiple 
      structural changes of the brain in IAD subjects. VBM results indicated the 
      decreased gray matter volume in the bilateral dorsolateral prefrontal cortex 
      (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the 
      cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA 
      value of the left posterior limb of the internal capsule (PLIC) and reduced FA 
      value in the white matter within the right parahippocampal gyrus (PHG). Gray 
      matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC 
      were significantly correlated with the duration of internet addiction in the 
      adolescents with IAD. CONCLUSIONS: Our results suggested that long-term internet 
      addiction would result in brain structural alterations, which probably 
      contributed to chronic dysfunction in subjects with IAD. The current study may 
      shed further light on the potential brain effects of IAD.
FAU - Yuan, Kai
AU  - Yuan K
AD  - School of Life Sciences and Technology, Life Sciences Research Center, Xidian 
      University, Xi'an, Shaanxi, China.
FAU - Qin, Wei
AU  - Qin W
FAU - Wang, Guihong
AU  - Wang G
FAU - Zeng, Fang
AU  - Zeng F
FAU - Zhao, Liyan
AU  - Zhao L
FAU - Yang, Xuejuan
AU  - Yang X
FAU - Liu, Peng
AU  - Liu P
FAU - Liu, Jixin
AU  - Liu J
FAU - Sun, Jinbo
AU  - Sun J
FAU - von Deneen, Karen M
AU  - von Deneen KM
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Liu, Yijun
AU  - Liu Y
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110603
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Behavior, Addictive/*pathology/physiopathology
MH  - Brain/*abnormalities
MH  - Diffusion Tensor Imaging/methods
MH  - Humans
MH  - *Internet
PMC - PMC3108989
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/06/17 06:00
MHDA- 2011/10/18 06:00
PMCR- 2011/06/03
CRDT- 2011/06/17 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
PHST- 2011/06/03 00:00 [pmc-release]
AID - PONE-D-11-00078 [pii]
AID - 10.1371/journal.pone.0020708 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(6):e20708. doi: 10.1371/journal.pone.0020708. Epub 2011 Jun 3.