PMID- 2167992
OWN - NLM
STAT- MEDLINE
DCOM- 19901004
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 53
IP  - 3
DP  - 1990 Jul
TI  - Roles of peripheral and central angiotensin-converting enzyme (ACE) in 
      hypovolemic thirst induced by compound 48/80 in rats.
PG  - 367-74
AB  - Subcutaneous (s.c.) injection of Hoe 498, an angiotensin converting enzyme (ACE) 
      inhibitor, at the doses of 0.1, 0.5, 1.0 and 4.0 mg/kg produced a dose-related 
      inhibition of compound 48/80-induced hypovolemic thirst in rats. A significant 
      time-response relationship was observed between the pretreatment time of Hoe 498 
      at a dose of 4.0 mg/kg and the inhibition of compound 48/80-induced water intake. 
      Nearly 90% of plasma ACE activity was inhibited by Hoe 498 at all doses used, and 
      this inhibition at the dose of 4.0 mg/kg of Hoe 498 continued for more than 4 hr. 
      Intracerebroventricular (i.c.v.) or s.c. injection of Hoe 498 in doses ranging 
      from 0.5 to 20 micrograms comparably inhibited plasma ACE activity in a 
      dose-dependent manner. The compound 48/80-induced water intake was significantly 
      reduced by i.c.v. injection of Hoe 498 (20 micrograms) 30 min after compound 
      48/80 administration, but not reduced when the drug was given 15 min prior to 
      injection of dipsogen. The inhibition of water intake by Hoe 498 seems to be 
      dependent on the dose and time between administration of Hoe 498 and compound 
      48/80. The present data suggest that brain ACE is more involved in compound 
      48/80-induced water intake than peripheral systemic ACE.
FAU - Izumi, H
AU  - Izumi H
AD  - Department of Physiology, Tohoku University School of Dentistry, Miyagi, Japan.
FAU - Hayashi, S
AU  - Hayashi S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Bridged Bicyclo Compounds)
RN  - 11128-99-7 (Angiotensin II)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - L35JN3I7SJ (Ramipril)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/pharmacology
MH  - Animals
MH  - Brain/drug effects/enzymology
MH  - Bridged Bicyclo Compounds/administration & dosage/pharmacology
MH  - Drinking/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptidyl-Dipeptidase A/*physiology
MH  - Ramipril
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thirst/drug effects/*physiology
MH  - p-Methoxy-N-methylphenethylamine/*pharmacology
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 10.1254/jjp.53.367 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1990 Jul;53(3):367-74. doi: 10.1254/jjp.53.367.