PMID- 21680603
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20110630
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 43
IP  - 7
DP  - 2011 Jul
TI  - Association of human cytomegalovirus viremia with human leukocyte antigens in 
      liver transplantation recipients.
PG  - 576-81
LID - 10.1093/abbs/gmr043 [doi]
AB  - Human cytomegalovirus (HCMV) reactivation is a common complication after liver 
      transplantation (LT). Here, we investigated whether human leukocyte antigen 
      (HLA)-matching was related to HCMV infection and subsequent graft failure after 
      LT for hepatitis B virus  cirrhosis. This retrospective study reviewed 91 LT 
      recipients. All the patients were grouped according to HLA-A, HLA-B, and HLA-DR 
      locus matching. Clinical data were collected, including complete HLA-typing, HCMV 
      viremia, graft failure, and the time of HCMV viremia. HLA typing was performed 
      using a sequence-specific primer-polymerase chain reaction  kit. HCMV was 
      detected by pp65 antigenemia using a commercial kit. The incidence of HCMV 
      infection post-LT was 81.32%. Graft failure was observed in 16 of 91 (17.6%) 
      patients during the 4-year study. The incidence of HCMV viremia was 100% (5/5), 
      91.4% (32/35), and 72.5% (37/51) in HLA-A two locus, one locus, and zero locus 
      compatibility, respectively. Nevertheless, the degree of the HLA-A, HLA-B, or 
      HLA-DR match did not influence the time of HCMV viremia, graft failure, or the 
      time of graft failure after a diagnosis of HCMV viremia (all P > 0.05). An 
      interesting discovery was that the risk of HCMV viremia tended to be higher in 
      patients with better HLA-A compatibility. Graft failure, time of HCMV viremia, 
      and graft failure after a diagnosis of HCMV viremia appear to be independent of 
      HLA allele compatibility.
FAU - Hu, Jianhua
AU  - Hu J
AD  - State key Laboratory for Diagnosis and Treatment of Infectious Diseases, the 
      First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 
      China.
FAU - Meng, Xueqin
AU  - Meng X
FAU - Zhao, Hong
AU  - Zhao H
FAU - Zhang, Xuan
AU  - Zhang X
FAU - Gao, Hainv
AU  - Gao H
FAU - Yang, Meifang
AU  - Yang M
FAU - Ma, Yadan
AU  - Ma Y
FAU - Li, Minhuan
AU  - Li M
FAU - Ma, Weihang
AU  - Ma W
FAU - Fan, Jun
AU  - Fan J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110616
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Blood Group Incompatibility/immunology
MH  - Cytomegalovirus Infections/*immunology
MH  - Female
MH  - Graft Rejection/immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - Liver Transplantation/*adverse effects/*immunology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Viremia/*immunology
EDAT- 2011/06/18 06:00
MHDA- 2011/10/21 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - gmr043 [pii]
AID - 10.1093/abbs/gmr043 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2011 Jul;43(7):576-81. doi: 
      10.1093/abbs/gmr043. Epub 2011 Jun 16.