PMID- 21681480
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 112
IP  - 3
DP  - 2012 Mar
TI  - Effects of mild-exercise training cessation in human skeletal muscle.
PG  - 853-69
LID - 10.1007/s00421-011-2036-7 [doi]
AB  - Stoppage of endurance exercise training leads to complete loss of maximal oxygen 
      uptake ([Formula: see text]) gain but not submaximal exercise blood lactate 
      concentrations. However, the detailed mechanisms are still unknown. Thus, we 
      investigated the effects of exercise-training cessation at lactate threshold (LT) 
      intensity on physiological adaptations and global mRNA expressions in human 
      skeletal muscle. The [Formula: see text], muscle capillaries density and global 
      gene expression were measured after 12 weeks of LT training, and after 12 weeks 
      of detraining. Twelve weeks of detraining reversed the effect of 12 weeks LT 
      training on [Formula: see text] and [Formula: see text] at LT intensity, although 
      the later value was higher than the pre-training level. Moreover, the training 
      cessation did not affect the number of capillaries around type I fiber, which was 
      increased by training. The training modulated 243 characterized transcripts, in 
      which 77% showed a significant reversible effect by detraining. However, the 
      transcripts most-induced by the training were still elevated after the same 
      period of detraining. The pathway and network analysis revealed that these genes 
      were related to oxidative phosphorylation (OxPhos), calcium signalling and tissue 
      development. Therefore, these physiological and transcriptional changes suggest 
      improved oxygen supply and OxPhos in the skeletal muscle, which may contribute to 
      the incomplete loss of absolute [Formula: see text] at LT intensity after 
      training cessation. The present study does not only demonstrate, for the first 
      time, sustained effects of training after detraining at the transcriptional 
      level, but also indicates the possible signalling pathways.
FAU - St-Amand, Jonny
AU  - St-Amand J
AD  - Department of Molecular Medicine, and Endocrinology and Genomics, CREMOGH, Laval 
      University, and CHUL-CRCHUQ, 2705 Boul. Laurier, Quebec, QC, G1V 4G2, Canada. 
      Jonny.St-Amand@crchul.ulaval.ca
FAU - Yoshioka, Mayumi
AU  - Yoshioka M
FAU - Nishida, Yuichiro
AU  - Nishida Y
FAU - Tobina, Takuro
AU  - Tobina T
FAU - Shono, Naoko
AU  - Shono N
FAU - Tanaka, Hiroaki
AU  - Tanaka H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110617
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (RNA, Messenger)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Adaptation, Physiological/genetics/physiology
MH  - Adult
MH  - Exercise/*physiology
MH  - Exercise Therapy
MH  - Gene Expression Profiling
MH  - Humans
MH  - Lactic Acid/analysis/blood/metabolism
MH  - Male
MH  - Muscle, Skeletal/metabolism/*physiology
MH  - Oxygen Consumption/physiology
MH  - *Physical Education and Training/methods
MH  - Physical Endurance/genetics/physiology
MH  - RNA, Messenger/analysis/metabolism
MH  - Withholding Treatment
MH  - Young Adult
EDAT- 2011/06/18 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/06/18 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1007/s00421-011-2036-7 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2012 Mar;112(3):853-69. doi: 10.1007/s00421-011-2036-7. Epub 
      2011 Jun 17.