PMID- 21681600
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20211020
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Apr
TI  - CD10 expression in epithelial and stromal cells of non-small cell lung carcinoma 
      (NSCLC): a clinic and pathologic correlation.
PG  - 153-60
LID - 10.1007/s12253-011-9421-8 [doi]
AB  - CD10 is a zinc dependent metallopeptidase, and its expression in stromal and/or 
      epithelial cells of many carcinomas has been suggested to have prognostic value. 
      This study investigates CD10 expression in epithelial and stromal cells of non 
      small cell lung carcinoma (NSCLC), and evaluates its prognostic value for this 
      tumor and its histologic subtypes. Sixty-six cases of NSCLC [35 cases of 
      nonsquamous cell carcinoma (NSCC) and 31 cases of squamous cell carcinoma (SCC)] 
      were analyzed immuno-histochemically for CD10 antibody. Fisher's exact test and 
      univariate survival analyses were performed. Comparison of clinicopathologic 
      characteristics for NSCLC showed that only stromal CD10 expression had worse 
      prognostic impact, associated with the presence of recurrence (p = 0.001), death 
      (p = 0.006) and disease positivity (p = 0.001). For SCC, CD10 was found to be 
      expressed mainly in the stromal cells, and was associated with a decreased 
      survival (p = 0.000) and disease free survival (p = 0.000). CD10 expression was 
      restricted to the epithelial cells in NSCC and associated with an increased 
      disease free survival (p = 0.036). Stromal CD10 expression apppears to be a worse 
      prognostic factor in NSCLCs. CD10 which is expressed in different cell components 
      of SCC and NSCC appears to have opposing effects on the behaviour of these 
      histologic types.
FAU - Gurel, Duygu
AU  - Gurel D
AD  - Department of Pathology, Faculty of Medicine, Dokuz Eylul University, Izmir, 
      Turkey. duygu.gurel@deu.edu.tr
FAU - Kargi, Aydanur
AU  - Kargi A
FAU - Karaman, Ilgin
AU  - Karaman I
FAU - Onen, Ahmet
AU  - Onen A
FAU - Unlu, Mehtat
AU  - Unlu M
LA  - eng
PT  - Journal Article
DEP - 20110618
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Adenocarcinoma/metabolism/mortality/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Large Cell/metabolism/mortality/pathology
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/mortality/*secondary
MH  - Carcinoma, Squamous Cell/metabolism/mortality/pathology
MH  - Epithelial Cells/*metabolism/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lung Neoplasms/*metabolism/mortality/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/metabolism/mortality/pathology
MH  - Neoplasm Staging
MH  - Neprilysin/*metabolism
MH  - Prognosis
MH  - Small Cell Lung Carcinoma/metabolism/mortality/pathology
MH  - Stromal Cells/*metabolism/pathology
MH  - Survival Rate
EDAT- 2011/06/18 06:00
MHDA- 2012/08/01 06:00
CRDT- 2011/06/18 06:00
PHST- 2010/10/15 00:00 [received]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1007/s12253-011-9421-8 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2012 Apr;18(2):153-60. doi: 10.1007/s12253-011-9421-8. Epub 
      2011 Jun 18.