PMID- 21682692
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20191112
IS  - 1875-6417 (Electronic)
IS  - 1573-3998 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Jul
TI  - Heat shock response regulates insulin sensitivity and glucose homeostasis: 
      pathophysiological impact and therapeutic potential.
PG  - 264-9
AB  - A large and increasing number of people in all over the world suffer from 
      obesity, metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Attenuation 
      of the heat shock response (HSR), which was originally identified as a cellular 
      defense mechanism, is one of the key factors involved in the deterioration of 
      metabolic abnormalities. On the other hand, activating the HSR increases heat 
      shock protein 72 (HSP72) expression and improves insulin resistance and glucose 
      homeostasis in rodents and humans, possibly by inhibiting the activation of 
      stress kinases such as c-jun terminal kinase (JNK) and inhibitor of kappa B 
      kinase beta (IKKbeta). These approaches may also reduce inflammatory cytokine 
      production and prevent the onset of atherogenic complications. This review 
      focuses on the physiological effects of HSR in regulating insulin sensitivity and 
      hyperglycemia, and the potential to target the HSR system for the treatment of MS 
      and T2DM, as well as other cellular stress-related diseases.
FAU - Kondo, Tatsuya
AU  - Kondo T
AD  - Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 
      1-1-1 Honjo, Kumamoto 860-8556, Japan.
FAU - Koga, Saori
AU  - Koga S
FAU - Matsuyama, Rina
AU  - Matsuyama R
FAU - Miyagawa, Katsutoshi
AU  - Miyagawa K
FAU - Goto, Rieko
AU  - Goto R
FAU - Kai, Hirofumi
AU  - Kai H
FAU - Araki, Eiichi
AU  - Araki E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Diabetes Rev
JT  - Current diabetes reviews
JID - 101253260
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology/*therapy
MH  - Glucose/*metabolism
MH  - Heat-Shock Response/*physiology
MH  - Homeostasis/physiology
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance/*physiology
MH  - Models, Biological
EDAT- 2011/06/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/21 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/06/12 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - BSP/CDR/E-Pub/00078 [pii]
AID - 10.2174/157339911796397811 [doi]
PST - ppublish
SO  - Curr Diabetes Rev. 2011 Jul;7(4):264-9. doi: 10.2174/157339911796397811.