PMID- 21682743
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20220318
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 242
IP  - 1
DP  - 2011 Jul
TI  - Basophils: emerging roles in the pathogenesis of allergic disease.
PG  - 144-60
LID - 10.1111/j.1600-065X.2011.01023.x [doi]
AB  - After approximately 130 years since their discovery as rare granulocytes that 
      circulate in blood, basophils are just now gaining respect as significant 
      contributors in the pathogenesis underlying allergic inflammation and disease. 
      While long known for secreting preformed and newly synthesized mediators and for 
      selectively infiltrating tissue during immunoglobulin E (IgE)-mediated 
      inflammation, their role has largely been viewed as redundant to that of tissue 
      mast cells in functioning as effector cells. This line of thought has persisted 
      even though it has been known in humans for approximately 20 years that basophils 
      additionally produce relatively large quantities of cytokines, e.g. interleukin-4 
      (IL-4)/IL-13, that are central for the manifestations of allergic disease. 
      Studies using novel IL-4 reporter mice have significantly added to the in vivo 
      importance of basophils as IL-4 producing cells, with recent findings indicating 
      that these cells also function as antigen-presenting cells essential in 
      initiating T-helper 2 responses. If confirmed and translated to humans, these 
      provocative findings will give new meaning to the role basophils have in allergic 
      disease, and in immunology overall.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Schroeder, John T
AU  - Schroeder JT
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, The Johns 
      Hopkins University School of Medicine, Baltimore, MD, USA. schray@jhmi.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Interleukin-13)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - *Basophils/immunology/metabolism
MH  - Cell Movement/immunology
MH  - Child
MH  - Histamine/biosynthesis/immunology
MH  - Humans
MH  - *Hypersensitivity/immunology/physiopathology
MH  - Immunity, Innate
MH  - Immunoglobulin E/*immunology
MH  - Inflammation/immunology
MH  - Interleukin-13/biosynthesis/*immunology
MH  - Interleukin-4/biosynthesis/*immunology
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Signal Transduction/immunology
MH  - Th2 Cells/*immunology/metabolism
EDAT- 2011/06/21 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 10.1111/j.1600-065X.2011.01023.x [doi]
PST - ppublish
SO  - Immunol Rev. 2011 Jul;242(1):144-60. doi: 10.1111/j.1600-065X.2011.01023.x.