PMID- 21683144
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211020
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Print)
IS  - 1044-7431 (Linking)
VI  - 48
IP  - 1
DP  - 2011 Sep
TI  - Hepatocyte growth factor acts as a mitogen and chemoattractant for postnatal 
      subventricular zone-olfactory bulb neurogenesis.
PG  - 38-50
LID - 10.1016/j.mcn.2011.06.003 [doi]
AB  - Neural progenitor cells persist throughout life in the forebrain subventricular 
      zone (SVZ). They generate neuroblasts that migrate to the olfactory bulb and 
      differentiate into interneurons, but mechanisms underlying these processes are 
      poorly understood. Hepatocyte growth factor/scatter factor (HGF/SF) is a 
      pleiotropic factor that influences cell motility, proliferation and morphogenesis 
      in neural and non-neural tissues. HGF and its receptor, c-Met, are present in the 
      rodent SVZ-olfactory bulb pathway. Using in vitro neurogenesis assays and in vivo 
      studies of partially HGF-deficient mice, we find that HGF promotes SVZ cell 
      proliferation and progenitor cell maintenance, while slowing differentiation and 
      possibly altering cell fate choices. HGF also acts as a chemoattractant for SVZ 
      neuroblasts in co-culture assays. Decreased HGF signaling induces ectopic SVZ 
      neuroblast migration and alters the timing of migration to the olfactory bulb. 
      These results suggest that HGF influences multiple steps in postnatal forebrain 
      neurogenesis. HGF is a mitogen for SVZ neural progenitors, and regulates their 
      differentiation and olfactory bulb migration.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Wang, Tsu-Wei
AU  - Wang TW
AD  - Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
FAU - Zhang, Huailin
AU  - Zhang H
FAU - Gyetko, Margaret R
AU  - Gyetko MR
FAU - Parent, Jack M
AU  - Parent JM
LA  - eng
GR  - R01 HD044775/HD/NICHD NIH HHS/United States
GR  - R01 HD044775-05/HD/NICHD NIH HHS/United States
GR  - HD44775/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110612
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Chemotactic Factors)
RN  - 0 (Mitogens)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - COS Cells
MH  - Cell Differentiation/physiology
MH  - Cell Movement/physiology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Chemotactic Factors/*metabolism
MH  - Chlorocebus aethiops
MH  - Hepatocyte Growth Factor/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mitogens/*metabolism
MH  - Neurogenesis/*physiology
MH  - Olfactory Bulb/*cytology/*embryology
MH  - Proto-Oncogene Proteins c-met/genetics/metabolism
MH  - Signal Transduction/physiology
MH  - Stem Cells/cytology/physiology
PMC - PMC3160177
MID - NIHMS310427
EDAT- 2011/06/21 06:00
MHDA- 2012/02/18 06:00
PMCR- 2012/09/01
CRDT- 2011/06/21 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2011/05/31 00:00 [revised]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - S1044-7431(11)00132-1 [pii]
AID - 10.1016/j.mcn.2011.06.003 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2011 Sep;48(1):38-50. doi: 10.1016/j.mcn.2011.06.003. Epub 
      2011 Jun 12.