PMID- 21686206
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 122
DP  - 2011
TI  - The role of CD23 in IgE dependent signaling: implications from pharmacogenetics.
PG  - 27-33
AB  - The association of immunoglobulin E (IgE) with allergic diseases and asthma is 
      well established. IgE binds to two receptors on various immune and inflammatory 
      cells. The lower-affinity IgE Fc receptor, CD23, has multiple functions in 
      enhancing the regulation of IgE production itself, and that of various 
      pro-inflammatory activities and mediators. The data in this report are derived 
      from an analysis of variation in the CD23 gene that leads to a coding exchange 
      and to a single nucleotide polymorphism (SNP) associated with the substitution of 
      an arginine residue for a tryptophan residue in the protein structure of CD23. 
      This genetic variation is associated with three findings identified in this 
      report. First, the tryptophan exchange is associated with greater expression of 
      RNA for the interleukin (IL)-4 receptor alpha chain and greater expression of RNA 
      for egr-1 transcription factor, both of which are proinflammatory gene products 
      that influence allergy-related immune functions. Second, the exchange is 
      associated with cell surface expression of IL-4R. Third, an analysis of potential 
      arginine-to-tryptophan exchanges in the entire human genome has identified a 
      number of interesting exchanges in immunologic genes of interest for their role 
      in allergic responses. A discussion of these three findings is presented.
FAU - Rosenwasser, Lanny J
AU  - Rosenwasser LJ
AD  - Allergy-Immunology Division, Children's Mercy Hospital, 2401 Gillham Road, Kansas 
      City, MO 64108, USA. lrosenwasser@cmh.edu
FAU - Meng, Jianfeng
AU  - Meng J
FAU - Chan, Marcia A
AU  - Chan MA
FAU - Gigliotti, Nicole M
AU  - Gigliotti NM
FAU - May, Brianna E
AU  - May BE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
RN  - 0 (EGR1 protein, human)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (IL4R protein, human)
RN  - 0 (Interleukin-4 Receptor alpha Subunit)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8DUH1N11BX (Tryptophan)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Amino Acid Substitution
MH  - Arginine
MH  - Asthma/*genetics/immunology
MH  - B-Lymphocytes/*immunology
MH  - Cell Line, Tumor
MH  - Early Growth Response Protein 1/genetics
MH  - Flow Cytometry
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology
MH  - Immunoglobulin E/*metabolism
MH  - Interleukin-4 Receptor alpha Subunit/genetics/metabolism
MH  - *Pharmacogenetics
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Conformation
MH  - Receptors, IgE/chemistry/*genetics/metabolism
MH  - *Signal Transduction
MH  - Structure-Activity Relationship
MH  - Transfection
MH  - Tryptophan
MH  - Up-Regulation
PMC - PMC3116349
COIS- Potential Conflicts of Interest: None disclosed
EDAT- 2010/01/01 00:00
MHDA- 2011/10/01 06:00
PMCR- 2011/01/01
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2011;122:27-33.