PMID- 21686515
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2009
DP  - 2009
TI  - Fatal giant cell myocarditis in a patient with multiple autoimmune disorders.
LID - bcr09.2008.0997 [pii]
LID - 10.1136/bcr.09.2008.0997 [doi]
AB  - A case of circulatory collapse due to severe heart failure is reported in a 
      52-year old male with autoimmune disorders in the form of type-1 diabetes, 
      Graves' disease and total alopecia.Upon admission, the patient had severe heart 
      failure with a cardiac index of 0.9 l/min/m(2), a mixed venous saturation of 29% 
      and left ventricular ejection fraction of 5%. The condition was refractory to 
      treatment with inotropic agents and required mechanical cardiopulmonary support. 
      Endomyocardial biopsies revealed extensive giant cell myocarditis (GCM). 
      Immunosuppressant treatment did not alter the condition and urgent orthotopic 
      heart transplantation was performed.Histopathological examination of the 
      explanted heart confirmed the diagnosis and showed widespread vascular deposition 
      of complement C4d suggesting a pathogenic role for the innate immune system in 
      GCM.At 1-year follow-up the patient was in New York Heart Association (NYHA) 
      class I, had episodes of sustained ventricular tachycardia but showed no evidence 
      of GCM recurrence in endomyocardial biopsies.
FAU - Rasmussen, Torsten Bloch
AU  - Rasmussen TB
AD  - Aarhus University Hospital, Dept. of Cardiology B, Brendstrupgaardsvej 100, 
      Aarhus, DK-8200 N, Denmark.
FAU - Dalager, Soren
AU  - Dalager S
FAU - Andersen, Niels Holmark
AU  - Andersen NH
FAU - Hansen, Troels Krarup
AU  - Hansen TK
FAU - Nielsen-Kudsk, Jens Erik
AU  - Nielsen-Kudsk JE
LA  - eng
PT  - Journal Article
DEP - 20090428
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
PMC - PMC3029067
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2011/04/28
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2011/04/28 00:00 [pmc-release]
AID - bcr09.2008.0997 [pii]
AID - 10.1136/bcr.09.2008.0997 [doi]
PST - ppublish
SO  - BMJ Case Rep. 2009;2009:bcr09.2008.0997. doi: 10.1136/bcr.09.2008.0997. Epub 2009 
      Apr 28.