PMID- 21688113
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20211020
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 118
IP  - 11
DP  - 2011 Nov
TI  - Neurocognitive-genetic and neuroimaging-genetic research paradigms in 
      schizophrenia and bipolar disorder.
PG  - 1621-39
LID - 10.1007/s00702-011-0672-z [doi]
AB  - Studies examining intermediate phenotypes such as neurocognitive and 
      neuroanatomical measures along with susceptibility genes are important for 
      improving our understanding of the neural basis of schizophrenia (SZ) and bipolar 
      disorder (BD). In this paper, we review extant studies involving 
      neurocognitive-genetic and neuroimaging-genetic perspectives and particularly 
      related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor 
      (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD. In terms of 
      neurocognitive-genetic investigations, COMT and BDNF are the two most studied 
      candidate genes especially in patients with SZ. Whereas BDNF Met carriers perform 
      worse on verbal working memory, problem solving and visuo-spatial abilities, COMT 
      Met carriers perform better in working memory, attention, executive functioning 
      with evidence of genotype by diagnosis interactions including high-risk 
      individuals. In terms of genetic-structural MRI studies, patients with SZ are 
      found to have reductions in the frontal, temporal, parietal cortices, and limbic 
      regions, which are associated with BDNF, COMT, and NRGI genes. Genetic-functional 
      MRI studies in psychotic disorders are sparse, especially with regard to BD. 
      These neurocognitive and neuroimaging findings are associated with genes which 
      are implicated in functional pathways related to neuronal signaling, 
      inter-neuronal communication and neuroplasticity.
FAU - Kurnianingsih, Yoanna Arlina
AU  - Kurnianingsih YA
AD  - Institute of Mental Health, Woodbridge Hospital, 10 Buangkok View, Singapore.
FAU - Kuswanto, Carissa Nadia
AU  - Kuswanto CN
FAU - McIntyre, Roger S
AU  - McIntyre RS
FAU - Qiu, Anqi
AU  - Qiu A
FAU - Ho, Beng Choon
AU  - Ho BC
FAU - Sim, Kang
AU  - Sim K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110619
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Bipolar Disorder/*diagnosis/*genetics/physiopathology
MH  - Cognition Disorders/*diagnosis/*genetics/physiopathology
MH  - Genetic Testing/methods
MH  - Humans
MH  - Neuroimaging/*methods
MH  - Neuropsychological Tests
MH  - Schizophrenia/*diagnosis/*genetics/physiopathology
EDAT- 2011/06/21 06:00
MHDA- 2012/08/01 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/03/04 00:00 [received]
PHST- 2011/06/05 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1007/s00702-011-0672-z [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2011 Nov;118(11):1621-39. doi: 
      10.1007/s00702-011-0672-z. Epub 2011 Jun 19.