PMID- 21688385
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20200930
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 156B
IP  - 6
DP  - 2011 Sep
TI  - No association observed between schizophrenia and non-HLA coeliac disease genes: 
      integration with the initial MYO9B association with coeliac disease.
PG  - 709-19
LID - 10.1002/ajmg.b.31213 [doi]
AB  - Schizophrenia is a severe psychotic illness with a heterogeneous presentation and 
      a devastating impact on social and occupational function. Worldwide variations in 
      schizophrenia incidence rates suggest that local conditions may modify disease 
      risk. The human leukocyte antigen (HLA) region has been confirmed to be 
      associated with schizophrenia by genome-wide association studies in populations 
      across the world. While the presence of autoimmune processes in a subgroup of 
      schizophrenia cases is contentious, the immune system could allow environmental 
      exposures to lead to schizophrenia by generating improper immune response. To 
      investigate this topic, we reviewed the current evidence of the relationship 
      between schizophrenia and coeliac disease. Based on this review, we performed 
      genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs 
      that have been previously associated with coeliac disease or schizophrenia in 223 
      families, 108 unrelated individuals with schizophrenia and 120 controls. Finding 
      no evidence for association with these two loci in our study samples, we applied 
      meta-analytic techniques to combine our findings with previous reports. This 
      synthesis, in light of our review of previous reports, suggests a differing 
      developmental trajectory for schizophrenia and coeliac disease. It is possible 
      that these two conditions do not share any functional overlap.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Law, Matthew H
AU  - Law MH
AD  - Genetics and Immunology Group, UHI Department of Diabetes and Cardiovascular 
      Science, Centre for Health Science, Inverness, UK.
FAU - Bradford, Matilda
AU  - Bradford M
FAU - McNamara, Neil
AU  - McNamara N
FAU - Gajda, Andy
AU  - Gajda A
FAU - Wei, Jun
AU  - Wei J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110617
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (HLA Antigens)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukins)
RN  - 0 (myosin IXB)
RN  - EC 3.6.4.1 (Myosins)
RN  - MKM3CA6LT1 (interleukin-21)
SB  - IM
MH  - Adult
MH  - Celiac Disease/complications/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens
MH  - Humans
MH  - Interleukin-2/*genetics
MH  - Interleukins/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myosins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Schizophrenia/complications/epidemiology/*genetics
EDAT- 2011/06/21 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/06/21 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - 10.1002/ajmg.b.31213 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):709-19. doi: 
      10.1002/ajmg.b.31213. Epub 2011 Jun 17.