PMID- 21688623
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 69
IP  - 6
DP  - 2011 Jun
TI  - [Proton pump inhibitor H2 receptor antagonist].
PG  - 1032-8
AB  - Recently, Japanese guidelines for the treatment and prevention of peptic ulcers 
      were established by the Japanese Society of Gastroenterology. Herein, we focus on 
      proton pump inhibitor(PPI) and H2 receptor antagonist (H2RA) for prophylaxis and 
      treatment of peptic ulcer associated with NSAIDs including low dose of aspirin. 
      Double dose of H2RAs are effective at preventing chronic NSAID related ulcers, 
      however, the effect is not superior to PPI. Full-dose misoprostol and PPI are 
      clinically equivalent, although the potential adverse effects of misoprostol are 
      a major cause of poor compliance. Overall, PPIs have the best profile of efficacy 
      and side-effects for the healing and prevention of NSAID-associated ulcers, 
      especially in the patients with high risk, such as history of peptic ulcer.
FAU - Shiotani, Akiko
AU  - Shiotani A
AD  - Department of Internal Medicine, Kawasaki Medical School.
FAU - Kamada, Tomoari
AU  - Kamada T
FAU - Kusunoki, Hiroaki
AU  - Kusunoki H
FAU - Manabe, Noriaki
AU  - Manabe N
FAU - Haruma, Ken
AU  - Haruma K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Peptic Ulcer/*chemically induced/*drug therapy/prevention & control
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2011/06/22 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2011 Jun;69(6):1032-8.