PMID- 21691937
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20220408
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 31
IP  - 5
DP  - 2011 Oct
TI  - Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), 
      osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with 
      lupus nephritis.
PG  - 848-56
LID - 10.1007/s10875-011-9555-1 [doi]
AB  - OBJECTIVE: This case-controlled study was designed to correlate urinary 
      biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), 
      monocyte chemoattractant protein-1 (MCP-1), and interleukin-8 (IL-8) levels, with 
      renal involvement in a cohort of systemic lupus erythematosus (SLE) patients to 
      examine their diagnostic performance. PATIENTS AND METHODS: In 73 SLE patients, 
      and in 23 healthy volunteers, urinary levels of TWEAK, OPG, MCP-1, and IL-8 
      levels were measured. Disease activity was assessed by total SLE disease activity 
      index, and renal activity by renal activity index (rSLEDAI), and both were 
      correlated with urinary biomarkers. Sensitivity, specificity, and predictive 
      values of individual biomarkers to predict lupus nephritis were also calculated. 
      RESULTS: Significantly higher levels of urinary biomarkers were observed in SLE 
      patients with lupus nephritis (LN) compared with those without LN (TWEAK, p < 
      0.001; MCP-1, p < 0.001; OPG, p < 0.001; IL-8, p < 0.032). Other significantly 
      higher levels were observed in SLE patients with LN compared with control 
      subjects (TWEAK, MCP-1, OPG, and IL-8 p < 0.001). Positive correlations were 
      observed between rSLEDAI and TWEAK (r = 0.612 and p < 0.001), MCP-1 (r = 0.635 
      and p < 0.001), and OPG (r = 0.505 and p < 0.001). CONCLUSIONS: Urinary levels of 
      TWEAK, OPG, and MCP-1 positively correlate with renal involvement as assessed by 
      rSLEDAI with reasonable sensitivity, specificity, and predictive values to detect 
      lupus nephritis while IL-8 was not significantly associated with global or 
      rSLEDAI.
FAU - El-Shehaby, Amal
AU  - El-Shehaby A
AD  - Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, 
      Egypt.
FAU - Darweesh, Hanan
AU  - Darweesh H
FAU - El-Khatib, Mohamed
AU  - El-Khatib M
FAU - Momtaz, Mohamed
AU  - Momtaz M
FAU - Marzouk, Samar
AU  - Marzouk S
FAU - El-Shaarawy, Nashwa
AU  - El-Shaarawy N
FAU - Emad, Yasser
AU  - Emad Y
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Biomarkers)
RN  - 0 (CD46 protein, human)
RN  - 0 (Cytokine TWEAK)
RN  - 0 (Interleukin-8)
RN  - 0 (Membrane Cofactor Protein)
RN  - 0 (Osteoprotegerin)
RN  - 0 (TNFSF12 protein, human)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Adult
MH  - Biomarkers/*urine
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cytokine TWEAK
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Interleukin-8/urine
MH  - Lupus Erythematosus, Systemic/*diagnosis/immunology/physiopathology
MH  - Lupus Nephritis
MH  - Male
MH  - Membrane Cofactor Protein/*urine
MH  - Molecular Targeted Therapy
MH  - Osteoprotegerin/*urine
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Tumor Necrosis Factors/*urine
EDAT- 2011/06/22 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1007/s10875-011-9555-1 [doi]
PST - ppublish
SO  - J Clin Immunol. 2011 Oct;31(5):848-56. doi: 10.1007/s10875-011-9555-1. Epub 2011 
      Jun 21.