PMID- 21692064
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20221207
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 118
IP  - 1
DP  - 2012 Jan 1
TI  - Associations of human leukocyte antigen class II genotypes with human 
      papillomavirus 18 infection and cervical intraepithelial neoplasia risk.
PG  - 223-31
LID - 10.1002/cncr.26227 [doi]
AB  - BACKGROUND: Only a small proportion of women infected with human papillomavirus 
      type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This 
      community-based cohort study aimed to assess associations with human leukocyte 
      antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent 
      risk of cervical neoplasia. METHODS: Among 10,190 cytologically normal 
      participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 
      viral load at study entry was examined by real-time polymerase chain reaction; 
      persistent infection was defined as HPV18 infection at 2 consecutive 
      examinations. RESULTS: There was a significant association between HLA-DRB1*0403 
      allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study 
      entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After 
      adjustment for age and viral load at study entry, haplotype 
      HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent 
      HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also 
      associated with a significantly increased risk of high-grade squamous 
      intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio 
      (95% CI) of 18.1 (2.6-128.5). CONCLUSIONS: HLA-DRB1*0403 allele and 
      HLA-DRB1*0405-DQA1*0301-DQB1*0302 haplotype may play important roles in 
      determination of high viral load and persistent infection of HPV18 and subsequent 
      cervical neoplasia risk.
CI  - Copyright (c) 2011 American Cancer Society.
FAU - Chuang, Li-Chung
AU  - Chuang LC
AD  - Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 
      Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
FAU - Hu, Chung-Yi
AU  - Hu CY
FAU - Chen, Hui-Chi
AU  - Chen HC
FAU - Lin, Pei-Jung
AU  - Lin PJ
FAU - Lee, Borheng
AU  - Lee B
FAU - Lin, Ching-Yu
AU  - Lin CY
FAU - Pan, Mei-Hung
AU  - Pan MH
FAU - You, San-Lin
AU  - You SL
FAU - Hsieh, Chang-Yao
AU  - Hsieh CY
FAU - Chen, Chien-Jen
AU  - Chen CJ
CN  - Community-Based Cancer Screening Program-Human Papillomavirus Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110620
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - *Human papillomavirus 18
MH  - Humans
MH  - Middle Aged
MH  - Papillomavirus Infections/*genetics
MH  - Risk Factors
MH  - Viral Load
MH  - Uterine Cervical Dysplasia/*genetics
EDAT- 2011/06/22 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/01/21 00:00 [received]
PHST- 2011/03/25 00:00 [revised]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1002/cncr.26227 [doi]
PST - ppublish
SO  - Cancer. 2012 Jan 1;118(1):223-31. doi: 10.1002/cncr.26227. Epub 2011 Jun 20.