PMID- 21692194
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20161125
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 46
IP  - 10
DP  - 2011 Oct
TI  - Chest radiographic presenting features and radiographic progression of 
      pneumocystis pneumonia in South African children.
PG  - 1015-22
LID - 10.1002/ppul.21465 [doi]
AB  - PURPOSE: To describe the radiographic features of PCP in South African children, 
      including the progression of changes and the impact of HIV-infection and 
      respiratory co-infections. METHODS: A paediatric radiologist blinded to clinical 
      details retrospectively reported the chest radiographs of children diagnosed with 
      PCP at a South Africa paediatric hospital between January 2003 and June 2006 
      inclusive. Radiographic features were correlated with clinical findings and 
      compared using Fisher's exact test and Wilcoxon's ranks-sum test. Institutional 
      ethics approval was obtained. RESULTS: Of 113 cases of PCP, 110 (97.3%) had 
      presenting and 96 (84.9%) follow-up radiographs; 88 (82%) were HIV-infected; 65 
      (59%) had respiratory co-infection; 48 (43%) died in hospital. The commonest 
      presenting radiographic findings were increased lung volumes (n = 86; 78%) and 
      diffuse parenchymal opacification (n = 70; 64%); 89 (92.7%) ultimately progressed 
      to diffuse alveolar opacification. Median time to maximum pulmonary opacification 
      was 72 hours (inter-quartile range (IQR): 24-144 hrs). Pulmonary interstitial 
      emphysema (PIE) developed in 33 patients (30%). There was no significant 
      difference in the radiographic features of PCP when comparison was made between 
      i) HIV-infected and -uninfected children, ii) those with and without respiratory 
      co-infection and iii) fatal cases and survivors (P > 0.05 in all cases). 
      CONCLUSION: Increased lung volumes and PIE should be recognised as features of 
      PCP in South African children. HIV-infection and respiratory co-infections do not 
      influence the radiographic features of PCP in our setting.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Pitcher, Richard D
AU  - Pitcher RD
AD  - Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, 
      Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa. 
      pitcher@sun.ac.za
FAU - Daya, Rupesh
AU  - Daya R
FAU - Beningfield, Stephen J
AU  - Beningfield SJ
FAU - Zar, Heather J
AU  - Zar HJ
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/complications
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pneumonia, Pneumocystis/complications/*diagnostic imaging
MH  - Radiography
MH  - Retrospective Studies
MH  - South Africa
EDAT- 2011/06/22 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/06/22 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2010/12/23 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 10.1002/ppul.21465 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2011 Oct;46(10):1015-22. doi: 10.1002/ppul.21465. Epub 2011 Jun 
      20.