PMID- 21693116
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20131121
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 667
IP  - 1-3
DP  - 2011 Sep 30
TI  - Carnosine pretreatment protects against hypoxia-ischemia brain damage in the 
      neonatal rat model.
PG  - 202-7
LID - 10.1016/j.ejphar.2011.06.003 [doi]
AB  - Perinatal hypoxia-ischemia brain injury is a major cause of mortality and 
      morbidity in neonates and lacks an effective treatment thus far. Carnosine has 
      been demonstrated to play a neuroprotective role in the adult brain injuries. 
      However, there is no information available concerning its neuroprotective role in 
      the immature brains after hypoxia-ischemia insults. Therefore, we investigated 
      whether carnosine could also confer neuroprotective effects in a neonatal rat 
      hypoxia-ischemia model. Hypoxia-ischemia was induced in rats on postnatal day 7 
      (P7). Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to 
      hypoxia-ischemia induction. Morphological brain injury and biochemical markers of 
      apoptosis and oxidative stress were evaluated 24 h after hypoxia-ischemia 
      induction. Cognitive performance was evaluated by the Morris Water Maze test on 
      P28-P33. We found that pretreatment with carnosine significantly reduced the 
      infarct volume and the number of terminal-deoxynucleotidyl transferase-mediated 
      dUTP nick end labeling (TUNEL)-positive cells in the hypoxia-ischemia brain. 
      Carnosine also inhibited mRNA expression of apoptosis-inducing factor(AIF) and 
      caspase-3, which was accompanied by an increase in superoxide 
      dismutase(SOD)activity and a decrease in the malondialdehyde(MDA)level in 
      carnosine-treated rats. Furthermore, carnosine also improved the spatial learning 
      and memory abilities of rats declined due to hypoxia-ischemia. These results 
      demonstrate that carnosine can protect rats against hypoxia-ischemia-induced 
      brain damage by antioxidation.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Zhang, Xiangmin
AU  - Zhang X
AD  - Department of Clinical Laboratory, Third Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, China.
FAU - Song, Lili
AU  - Song L
FAU - Cheng, Xiuyong
AU  - Cheng X
FAU - Yang, Yi
AU  - Yang Y
FAU - Luan, Bin
AU  - Luan B
FAU - Jia, Liting
AU  - Jia L
FAU - Xu, Falin
AU  - Xu F
FAU - Zhang, Zhan
AU  - Zhang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110616
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antioxidants)
RN  - 0 (Apoptosis Inducing Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (RNA, Messenger)
RN  - 8HO6PVN24W (Carnosine)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*pharmacology/therapeutic use
MH  - Apoptosis/drug effects
MH  - Apoptosis Inducing Factor/genetics
MH  - Brain/drug effects/metabolism/pathology/physiopathology
MH  - Brain Infarction/drug therapy/pathology/physiopathology
MH  - Carnosine/*pharmacology/therapeutic use
MH  - Caspase 3/genetics
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Hypoxia-Ischemia, Brain/metabolism/*pathology/physiopathology/*prevention & 
      control
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Neurons/drug effects/metabolism/pathology
MH  - Neuroprotective Agents/*pharmacology/therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Pregnancy
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spatial Behavior/drug effects/physiology
MH  - Survival Analysis
MH  - Time Factors
EDAT- 2011/06/23 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/01/05 00:00 [received]
PHST- 2011/05/21 00:00 [revised]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0014-2999(11)00686-8 [pii]
AID - 10.1016/j.ejphar.2011.06.003 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2011 Sep 30;667(1-3):202-7. doi: 10.1016/j.ejphar.2011.06.003. 
      Epub 2011 Jun 16.