PMID- 21693613
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220317
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 8
DP  - 2011 Jul 29
TI  - Early perfusion of a free RPE-choroid graft in patients with exudative macular 
      degeneration can be imaged with spectral domain-OCT.
PG  - 5881-6
LID - 10.1167/iovs.11-7245 [doi]
AB  - PURPOSE: To study early flow and revascularization in a free, autologous, retinal 
      pigment epithelium (RPE)-choroid graft. METHODS: This prospective cohort study 
      used spectral domain-optical coherence tomography (SD-OCT) after RPE-choroid 
      graft surgery in 12 patients. This SD-OCT was combined with fluorescein 
      angiography (FA) and indocyanine green angiography (ICGA) in 5 patients. RESULTS: 
      SD-OCT revealed that vessel diameter, number of vessels, and graft thickness 
      increased in 10 of 12 patients, starting between 3 and 10 days after surgery. A 
      subsequent decrease in thickness was found in all 10 patients, beginning as early 
      as 8 days after surgery. Initially, the graft vessels were optically clearer than 
      the underlying choroidal recipient vessels. Between 8 and 30 days after surgery, 
      the optically clear vessels became gray, similar to the recipient choroid. FA and 
      ICGA revealed perfusion in 4 of 5 patients between postoperative days 6 and 15. 
      Between postoperative days 12 and 60, the entire choroidal structure of the graft 
      was visible on ICGA. CONCLUSIONS; These data suggest that enlargement of vessel 
      diameter, increase in the number of choroidal vessels, and graft thickening 
      visualized by SD-OCT correspond with the ingrowth of afferent vessels, as 
      demonstrated by ICGA. The subsequent establishment of efferent vessels results in 
      flow, imaged as a change in color of the graft's vessels from optically clear to 
      gray, graft thinning on SD-OCT, and complete revascularization on ICGA. SD-OCT, a 
      noninvasive examination, can be used to demonstrate early graft perfusion in 
      patients (trialregister.nl/trialreg/admin/rctview.asp number, NTR1768).
FAU - van Zeeburg, Elsbeth J T
AU  - van Zeeburg EJ
AD  - The Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands. 
      elsbethvanzeeburg@hotmail.com
FAU - Cereda, Matteo G
AU  - Cereda MG
FAU - van der Schoot, Josine
AU  - van der Schoot J
FAU - Pertile, Grazia
AU  - Pertile G
FAU - van Meurs, Jan C
AU  - van Meurs JC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110729
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*transplantation
MH  - Coloring Agents
MH  - Exudates and Transudates
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green
MH  - Macular Degeneration/*pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Pigment Epithelium/*transplantation
MH  - Tomography, Optical Coherence/*methods
EDAT- 2011/06/23 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - iovs.11-7245 [pii]
AID - 10.1167/iovs.11-7245 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5881-6. doi: 10.1167/iovs.11-7245.