PMID- 21695550
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 63
IP  - 11
DP  - 2011 Nov
TI  - HLA class I allele promiscuity revisited.
PG  - 691-701
LID - 10.1007/s00251-011-0552-6 [doi]
AB  - The peptide repertoire presented on human leukocyte antigen (HLA) class I 
      molecules is largely determined by the structure of the peptide binding groove. 
      It is expected that the molecules having similar grooves (i.e., belonging to the 
      same supertype) might present similar/overlapping peptides. However, the extent 
      of promiscuity among HLA class I ligands remains controversial: while in many 
      studies T cell responses are detected against epitopes presented by alternative 
      molecules across HLA class I supertypes and loci, peptide elution studies report 
      minute overlaps between the peptide repertoires of even related HLA molecules. To 
      get more insight into the promiscuous peptide binding by HLA molecules, we 
      analyzed the HLA peptide binding data from the large epitope repository, Immune 
      Epitope Database (IEDB), and further performed in silico analysis to estimate the 
      promiscuity at the population level. Both analyses suggest that an unexpectedly 
      large fraction of HLA ligands (> 50%) bind two or more HLA molecules, often 
      across supertype or even loci. These results suggest that different HLA class I 
      molecules can nevertheless present largely overlapping peptide sets, and that 
      "functional" HLA polymorphism on individual and population level is probably much 
      lower than previously anticipated.
FAU - Rao, Xiangyu
AU  - Rao X
AD  - Theoretical Biology and Bioinformatics, Utrecht University, Padualaan 8, 3584CH 
      Utrecht, The Netherlands.
FAU - Hoof, Ilka
AU  - Hoof I
FAU - Costa, Ana Isabel C A Fontaine
AU  - Costa AI
FAU - van Baarle, Debbie
AU  - van Baarle D
FAU - Kesmir, Can
AU  - Kesmir C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110622
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Peptides)
SB  - IM
MH  - Alleles
MH  - Antigen Presentation/*immunology
MH  - Databases, Protein
MH  - Epitopes, T-Lymphocyte/chemistry/genetics/*immunology
MH  - HLA Antigens/chemistry/genetics/*immunology
MH  - Humans
MH  - Peptides/chemistry/immunology
MH  - Protein Binding/immunology
PMC - PMC3190086
EDAT- 2011/06/23 06:00
MHDA- 2011/12/13 00:00
PMCR- 2011/06/22
CRDT- 2011/06/23 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2011/06/22 00:00 [pmc-release]
AID - 552 [pii]
AID - 10.1007/s00251-011-0552-6 [doi]
PST - ppublish
SO  - Immunogenetics. 2011 Nov;63(11):691-701. doi: 10.1007/s00251-011-0552-6. Epub 
      2011 Jun 22.