PMID- 21695767
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20211020
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Print)
IS  - 1520-7552 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan
TI  - Type 2 diabetes affects hippocampus volume differentially in men and women.
PG  - 76-83
LID - 10.1002/dmrr.1230 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) has been shown to result in medical 
      complications on several organ systems including the kidneys, eyes, 
      cardiovascular system, and most recently described the brain, including the 
      hippocampus. There is also evidence that females are disproportionately affected 
      by these medical complications. Brain volume reductions have also been associated 
      with chronic low-grade inflammation and dyslipidaemia. This study investigated 
      the relationships among T2DM, gender, inflammation, dyslipidaemia, and 
      hippocampal volumes. METHOD: Participant groups consisted of 40 obese adults with 
      T2DM and 47 lean adults, group-matched on age, gender, race, and education. Each 
      participant underwent medical examination including a standard panel of blood 
      tests, a magnetic resonance imaging, and cognitive evaluation. RESULTS: We show 
      that there is a gender difference in the association of T2DM and hippocampal 
      volumes: diabetic women are most affected despite having better glucose control 
      than their male counterparts. Although females with T2DM had disproportionately 
      lower high density lipoprotein as well as better haemoglobin A1c, neither of 
      these results explained why females with T2DM had the smallest hippocampal 
      volumes. CONCLUSIONS: These important findings indicate that in addition to the 
      higher rate of traditional medical complication, females with T2DM are likely to 
      suffer more brain complications than males. These observations, if supported by 
      larger studies, suggest that in the future gender could be considered when 
      customizing diabetes treatment.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Hempel, R
AU  - Hempel R
AD  - Department of Psychiatry, New York University School of Medicine, New York, NY, 
      USA.
FAU - Onopa, R
AU  - Onopa R
FAU - Convit, Antonio
AU  - Convit A
LA  - eng
GR  - UL1 RR029893-03/RR/NCRR NIH HHS/United States
GR  - 1UL1RR029893/RR/NCRR NIH HHS/United States
GR  - R01 DK064087/DK/NIDDK NIH HHS/United States
GR  - DK064087/DK/NIDDK NIH HHS/United States
GR  - TL1 RR029892/RR/NCRR NIH HHS/United States
GR  - R01 DK064087-07/DK/NIDDK NIH HHS/United States
GR  - UL1 RR029893/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/*pathology
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Sex Factors
PMC - PMC3273865
MID - NIHMS353725
EDAT- 2011/06/23 06:00
MHDA- 2012/03/07 06:00
PMCR- 2013/01/01
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.1002/dmrr.1230 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2012 Jan;28(1):76-83. doi: 10.1002/dmrr.1230.