PMID- 21696072
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110623
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 94
IP  - 6
DP  - 2011 Jun
TI  - Intra-coronary bone marrow mononuclear cell transplantation in patients with 
      ST-elevation myocardial infarction: a randomized controlled study.
PG  - 657-63
AB  - BACKGROUND: Stem cell transplantation is a potential treatment to improve left 
      ventricular ejection fraction (LVEF) after ST elevation myocardial infarction 
      (STEMI). However, the outcomes still are controversial. OBJECTIVE: To determine 
      the 6-month LVEF of the patients who underwent intra-coronary bone marrow 
      mononuclear cell (BMC) transplantation in patients with STEMI compared with 
      controlled subjects. MATERIAL AND METHOD: After successful percutaneous coronary 
      intervention (PCI) in STEMI patients who had LVEF was less than 50% were 
      randomized to intra-coronary BMC transplantation or control. Bone marrow 
      aspiration of 100 cc was performed in the morning. After cellprocessing for three 
      hours, the suspension of BMC about 10 cc were infused to infracted area using 
      standard PCI technique. Balloon occlusion for three minutes was performed during 
      cell infusion. Cardiac magnetic resonance imaging was used to determine LVEF scar 
      volume and LV volume before and six-month follow-up. RESULTS: Between September 
      2006 and July 2008, 23patients (11 in BMC group and 12 in control group) were 
      enrolled. Mean BMC count before transplant was 420 x 10(6) cell with 96% 
      viability. At six-month follow-up, New York Heart Association function class 
      significantly improved in both groups (2.3 +/- 0.6 to 1.2 +/- 0. 4 for BMC and 
      2.3 +/- 0.7 to 1.3 +/- 0.5 for control group) but no difference was seen between 
      groups. However, scar volume, wall motion score index, and LVEF did not show 
      improvement after six months in both groups (33.7 +/- 7.7 to 33.5 +/- 7.6 for BMC 
      and 31.1 +/- 7.1 to 32.6 +/- 8.3 for control group). No complication was observed 
      during the procedure. CONCLUSION: BMC transplantation intra-coronary in patients 
      with STEMI in KCMH was feasible and safe but LVEF improvement could not be 
      demonstrated.
FAU - Srimahachota, Suphot
AU  - Srimahachota S
AD  - Division of Cardiology, Department of Medicine, King Chulalongkorn Memorial 
      Hospital, Bangkok, Thailand. s_srimahachota@yahoo.co.th
FAU - Boonyaratavej, Smonporn
AU  - Boonyaratavej S
FAU - Rerkpattanapipat, Pairoj
AU  - Rerkpattanapipat P
FAU - Wangsupachart, Somjai
AU  - Wangsupachart S
FAU - Tumkosit, Monravee
AU  - Tumkosit M
FAU - Bunworasate, Udomsak
AU  - Bunworasate U
FAU - Nakorn, Thayapong Na
AU  - Nakorn TN
FAU - Intragumtornchai, Tanin
AU  - Intragumtornchai T
FAU - Kupatawintu, Pawinee
AU  - Kupatawintu P
FAU - Pongam, Sunisa
AU  - Pongam S
FAU - Saengsiri, Aem-Orn
AU  - Saengsiri AO
FAU - Pothisri, Mantana
AU  - Pothisri M
FAU - Sukseri, Yeesoon
AU  - Sukseri Y
FAU - Bunprasert, Tanorm
AU  - Bunprasert T
FAU - Suithichaiyakul, Taworn
AU  - Suithichaiyakul T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary
MH  - Bone Marrow Cells/pathology
MH  - *Bone Marrow Transplantation
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Injections, Intra-Arterial
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/physiopathology/*therapy
MH  - Stem Cell Transplantation
MH  - Stroke Volume/physiology
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Ventricular Function, Left/physiology
EDAT- 2011/06/24 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2011 Jun;94(6):657-63.