PMID- 2169620
OWN - NLM
STAT- MEDLINE
DCOM- 19901024
LR  - 20201209
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 87
IP  - 18
DP  - 1990 Sep
TI  - Trans-activation of HLA-DR gene by hepatitis B virus X gene product.
PG  - 7140-4
AB  - Hepatocellular injury during hepatitis B virus (HBV) infection has been 
      postulated to result from a human leukocyte antigen (HLA)-restricted T-lymphocyte 
      host immune response against HBV antigens. Although HLA expression is enhanced in 
      the presence of hepatic inflammation, whether HBV itself can induce HLA 
      expression on infected hepatocytes is unknown. In this study, we demonstrate the 
      induction of HLA-DR expression on human hepatoma cell lines transfected with HBV 
      DNA sequences. The HBV X gene alone was capable of inducing HLA-DR expression. 
      This induction correlated with elevated HLA-DR RNA, and this resulted directly 
      from transcriptional trans-activation of the HLA-DR gene by the HBV X protein. 
      These studies suggest that the HBV X protein can regulate the expression of 
      HLA-DR and thus raise the possibility of participation by the X gene in the 
      immunopathogenesis of HBV infection.
FAU - Hu, K Q
AU  - Hu KQ
AD  - Department of Microbiology and Immunology, University of Colorado School of 
      Medicine, Denver 80262.
FAU - Vierling, J M
AU  - Vierling JM
FAU - Siddiqui, A
AU  - Siddiqui A
LA  - eng
GR  - 1P30 AM34914/AM/NIADDK NIH HHS/United States
GR  - CA 333135/CA/NCI NIH HHS/United States
GR  - DK33883/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antigens, Viral)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Trans-Activators)
RN  - 0 (Viral Regulatory and Accessory Proteins)
RN  - 0 (hepatitis B virus X protein)
SB  - IM
MH  - Antigens, Viral/genetics
MH  - Carcinoma, Hepatocellular
MH  - Cell Line
MH  - *Genes, Viral
MH  - Genetic Vectors
MH  - HLA-DR Antigens/analysis/*genetics
MH  - Hepatitis B virus/*genetics
MH  - Humans
MH  - Liver Neoplasms
MH  - Plasmids
MH  - Restriction Mapping
MH  - Trans-Activators/analysis/*genetics
MH  - *Transcriptional Activation
MH  - Transfection
MH  - Viral Regulatory and Accessory Proteins
PMC - PMC54699
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
PMCR- 1991/03/01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
PHST- 1991/03/01 00:00 [pmc-release]
AID - 10.1073/pnas.87.18.7140 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1990 Sep;87(18):7140-4. doi: 10.1073/pnas.87.18.7140.