PMID- 21696342
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20191210
IS  - 1874-4745 (Electronic)
IS  - 1874-4737 (Linking)
VI  - 4
IP  - 2
DP  - 2011 Jun
TI  - MDMA & cannabis: a mini-review of cognitive, behavioral, and neurobiological 
      effects of co-consumption.
PG  - 81-6
AB  - Although the prevalence of co-use of cannabis and 3,4 
      methylenedioxymethamphetamine (MDMA) is very common among polydrug users in 
      western societies, few studies have tested the consequences on behavior, 
      cognition or neurobiology. This review examines 23 articles published between 
      2002 and 2010 with an explicit focus on the combination, or administration, of 
      MDMA and cannabis or cannabinoid agents. The aim was to provide a short overview 
      on the latest human research concerning cognitive effects of co-consumption of 
      MDMA and cannabis, and a more elaborate picture of the state of knowledge about 
      the interaction of cannabinoid agents and MDMA from animal studies. It was found 
      that recent retrospective studies on cognitive functions in long-term drug 
      abusers point to an additive negative effect on different types of memory, as 
      well as a cannabis-independent decrease in learning and decision-making in MDMA 
      users. Behavioral experiments in rodents and in vitro studies investigating the 
      combined effect of MDMA and cannabinoid agents demonstrate modulator effects of 
      acute co-administration on measures like body temperature, conditioned 
      reinforcement, and presumed neurotoxicity. As neural mechanism underlying these 
      changes, an interaction between the cannabinoid system, especially cannabinoid 
      receptor 1, and the serotonergic and dopaminergic system in the prefrontal 
      cortex, nucleus accumbens, and hippocampus is suggested. In conclusion, there are 
      few and somewhat contradictory studies examining the effects of co-use of these 
      drugs on cognitive measures like impulsivity, memory and executive functions or 
      underlying neurobiological alterations, and a shortage of animal studies 
      examining long-term effects of chronic co-administration.
FAU - Schulz, Sybille
AU  - Schulz S
AD  - Brain Research Institute, Department of Neuropharmacology, University of Bremen, 
      D-28359 Bremen, Germany. s.schulz@uni-bremen.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Abuse Rev
JT  - Current drug abuse reviews
JID - 101468123
RN  - 0 (Cannabinoids)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Brain/drug effects
MH  - Cannabinoids/adverse effects
MH  - Cannabis/*adverse effects
MH  - Cognition/*drug effects
MH  - Conditioning, Psychological/*drug effects
MH  - *Herb-Drug Interactions
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*adverse effects
MH  - Synaptic Transmission/*drug effects
EDAT- 2011/06/24 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/06/09 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - BSP/CDAR/E-Pub/00035 [pii]
AID - 10.2174/1874473711104020081 [doi]
PST - ppublish
SO  - Curr Drug Abuse Rev. 2011 Jun;4(2):81-6. doi: 10.2174/1874473711104020081.