PMID- 21696830
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20220317
IS  - 0165-1781 (Print)
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 190
IP  - 2-3
DP  - 2011 Dec 30
TI  - Medication adherence and attitudes in patients with bipolar disorder and current 
      versus past substance use disorder.
PG  - 253-8
LID - 10.1016/j.psychres.2011.05.042 [doi]
AB  - We examined the impact of substance use disorder (SUD) history among patients 
      with bipolar I disorder (BD) in regards to medication-taking behaviors and 
      attitudes. Interviews were conducted with inpatients hospitalized for BD, which 
      included diagnostic instruments and measures of attitudes concerning psychiatric 
      medications. We compared patients with BD and no history of SUD (BD-NH), BD and 
      past history of SUD (BD-PH), and BD and current SUD (BD-C). The primary outcome 
      variable was a standardized medication adherence ratio (SMAR) of [medication 
      taken]/[medication prescribed]. Fifty-four patients with a BD diagnosis 
      participated, which included BD-NH (n=26), BD-PH (n=19), and BD-C (n=9). The SMAR 
      was significantly different among the three groups; post-hoc analyses revealed 
      the SMAR was significantly lower among BD-C (M=0.70) compared to BD-NH (M=0.90) 
      and BD-PH (M=0.97) patients. This finding remained significant after controlling 
      for numerous patient characteristics. Attitudes regarding medications, measured 
      by the Drug Attitude Inventory (DAI), were positive among a significantly higher 
      percentage of BD-PH (89.47%) and BD-NH (65.38%) compared to BD-C (44.44%) 
      patients. In conclusion, patients with BD-C demonstrated poor medication 
      adherence and attitudes concerning medication management. Helping patients with 
      BD achieve remission from SUD may lead to a more successful course of BD 
      pharmacotherapy.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Teter, Christian J
AU  - Teter CJ
AD  - Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA, USA. 
      cteter@une.edu
FAU - Falone, Anthony E
AU  - Falone AE
FAU - Bakaian, Amanda M
AU  - Bakaian AM
FAU - Tu, Chunhao
AU  - Tu C
FAU - Ongur, Dost
AU  - Ongur D
FAU - Weiss, Roger D
AU  - Weiss RD
LA  - eng
GR  - K24 DA022288/DA/NIDA NIH HHS/United States
GR  - K24 DA022288-05/DA/NIDA NIH HHS/United States
GR  - L30 DA023799/DA/NIDA NIH HHS/United States
GR  - L30 DA023799-01/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110622
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - *Attitude to Health
MH  - Bipolar Disorder/drug therapy/epidemiology/*psychology
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Substance-Related Disorders/drug therapy/epidemiology/*psychology
PMC - PMC3663075
MID - NIHMS307649
EDAT- 2011/06/24 06:00
MHDA- 2012/02/09 06:00
PMCR- 2013/05/24
CRDT- 2011/06/24 06:00
PHST- 2010/05/26 00:00 [received]
PHST- 2011/05/24 00:00 [revised]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
PHST- 2013/05/24 00:00 [pmc-release]
AID - S0165-1781(11)00439-2 [pii]
AID - 10.1016/j.psychres.2011.05.042 [doi]
PST - ppublish
SO  - Psychiatry Res. 2011 Dec 30;190(2-3):253-8. doi: 10.1016/j.psychres.2011.05.042. 
      Epub 2011 Jun 22.