PMID- 21696985
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20120410
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 192
IP  - 1
DP  - 2012 Apr
TI  - Circulating cytokine concentrations in dogs with different degrees of myxomatous 
      mitral valve disease.
PG  - 106-11
LID - 10.1016/j.tvjl.2011.05.009 [doi]
AB  - Cytokines have been associated with the progression of congestive heart failure 
      (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral 
      valve disease (MMVD) in dogs. The aim of this study was to determine the serum 
      concentrations of cytokines in dogs with MMVD. The study included 16 Cairn 
      terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles 
      Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with 
      CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-gamma, 
      interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived 
      chemokine, interferon-gamma-induced protein and monocyte chemoattractant protein-1 
      (MCP-1) were measured using a canine-specific multiplex immunoassay. CHF dogs had 
      significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among 
      the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also 
      decreased with increasing MR. IL-8 decreased with increasing left ventricular 
      end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to 
      healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of 
      disease severity. The results suggest a role for these cytokines in canine MMVD 
      and CHF.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Zois, Nora E
AU  - Zois NE
AD  - Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, 
      University of Copenhagen, Frederiksberg, Denmark. nez@life.ku.dk
FAU - Moesgaard, Sophia G
AU  - Moesgaard SG
FAU - Kjelgaard-Hansen, Mads
AU  - Kjelgaard-Hansen M
FAU - Rasmussen, Caroline E
AU  - Rasmussen CE
FAU - Falk, Torkel
AU  - Falk T
FAU - Fossing, Christine
AU  - Fossing C
FAU - Haggstrom, Jens
AU  - Haggstrom J
FAU - Pedersen, Henrik D
AU  - Pedersen HD
FAU - Olsen, Lisbeth H
AU  - Olsen LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110621
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/*blood/immunology/metabolism
MH  - Denmark
MH  - Dog Diseases/immunology/*physiopathology
MH  - Dogs
MH  - Down-Regulation
MH  - Echocardiography/veterinary
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Heart Failure/immunology/physiopathology/*veterinary
MH  - Heart Valve Diseases/immunology/physiopathology/*veterinary
MH  - Heart Ventricles/immunology/physiopathology
MH  - Immunoassay/veterinary
MH  - Least-Squares Analysis
MH  - Male
MH  - Mitral Valve/immunology/*physiopathology
MH  - Species Specificity
MH  - Statistics, Nonparametric
MH  - Ventricular Function
EDAT- 2011/06/24 06:00
MHDA- 2012/08/07 06:00
CRDT- 2011/06/24 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/05/05 00:00 [revised]
PHST- 2011/05/07 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - S1090-0233(11)00182-1 [pii]
AID - 10.1016/j.tvjl.2011.05.009 [doi]
PST - ppublish
SO  - Vet J. 2012 Apr;192(1):106-11. doi: 10.1016/j.tvjl.2011.05.009. Epub 2011 Jun 21.